Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.
Song CQ, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte D, Zender L, Wang XW, Thorgeirsson S, Weng Z, Xue W. Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. Gastroenterology. 2017 04; 152(5):1161-1173.e1.
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Animals
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Benzimidazoles
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Blotting, Western
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Butadienes
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Carcinoma, Hepatocellular
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Cell Line, Tumor
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CRISPR-Cas Systems
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Cytoskeletal Proteins
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DNA, Neoplasm
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Enzyme Inhibitors
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Gene Expression Regulation, Neoplastic
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Genes, Neurofibromatosis 1
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Genome-Wide Association Study
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Hepatocytes
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High-Throughput Nucleotide Sequencing
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HMGA Proteins
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HMGA2 Protein
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Humans
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Immunohistochemistry
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Liver Neoplasms
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Liver Neoplasms, Experimental
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Membrane Glycoproteins
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Mice
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Mice, Knockout
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Mice, Nude
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Mitogen-Activated Protein Kinases
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Nerve Tissue Proteins
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Niacinamide
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Nitriles
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Phenylurea Compounds
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Prognosis
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Protein Kinase Inhibitors
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Proto-Oncogene Proteins c-myc
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Pyridones
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Pyrimidinones
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ras Proteins
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Real-Time Polymerase Chain Reaction
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Receptors, Cell Surface
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Sequence Analysis, DNA
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Survival Analysis
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins