"MutL Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
| Descriptor ID |
D000070956
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| MeSH Number(s) |
D08.811.074.766 D08.811.277.040.025.215 D12.776.260.540
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "MutL Proteins".
Below are MeSH descriptors whose meaning is more specific than "MutL Proteins".
This graph shows the total number of publications written about "MutL Proteins" by people in this website by year, and whether "MutL Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "MutL Proteins" by people in Profiles.
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Siehler SY, Schrauder M, Gerischer U, Cantor S, Marra G, Wiesm?ller L. Human MutL-complexes monitor homologous recombination independently of mismatch repair. DNA Repair (Amst). 2009 Feb 01; 8(2):242-52.
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Peng M, Litman R, Xie J, Sharma S, Brosh RM, Cantor SB. The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J. 2007 Jul 11; 26(13):3238-49.
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L?pez de Saro FJ, Marinus MG, Modrich P, O'Donnell M. The beta sliding clamp binds to multiple sites within MutL and MutS. J Biol Chem. 2006 May 19; 281(20):14340-9.
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Calmann MA, Evans JE, Marinus MG. MutS inhibits RecA-mediated strand transfer with methylated DNA substrates. Nucleic Acids Res. 2005; 33(11):3591-7.
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Wu TH, Loh T, Marinus MG. The function of Asp70, Glu77 and Lys79 in the Escherichia coli MutH protein. Nucleic Acids Res. 2002 Feb 01; 30(3):818-22.
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Wu TH, Marinus MG. Deletion mutation analysis of the mutS gene in Escherichia coli. J Biol Chem. 1999 Feb 26; 274(9):5948-52.
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Drotschmann K, Aronshtam A, Fritz HJ, Marinus MG. The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA. Nucleic Acids Res. 1998 Feb 15; 26(4):948-53.
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Aronshtam A, Marinus MG. Dominant negative mutator mutations in the mutL gene of Escherichia coli. Nucleic Acids Res. 1996 Jul 01; 24(13):2498-504.