A549 Cells

"A549 Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An immortalized cell line derived from human ADENOCARCINOMA, ALVEOLAR basal epithelial cells isolated from the lungs of a male patient in 1972. The cell line is positive for KERATIN, can synthesize LECITHIN, and contains high levels of POLYUNSATURATED FATTY ACIDS in its PLASMA MEMBRANE. It is used as a model for PULMONARY ALVEOLI function and virus infections, as a TRANSFECTION host, and for PRECLINICAL DRUG EVALUATION.

Descriptor ID	D000072283
MeSH Number(s)	A11.251.210.190.080 A11.251.860.180.080 A11.436.054
Concept/Terms	A549 Cells A549 Cells A549 Cell Cell, A549 Cells, A549 A549 Cell Line A549 Cell Lines Cell Line, A549 Cell Lines, A549

Below are MeSH descriptors whose meaning is more general than "A549 Cells".

Anatomy [A]
Cells [A11]
Cells, Cultured [A11.251]
Cell Line [A11.251.210]
Cell Line, Tumor [A11.251.210.190]
A549 Cells [A11.251.210.190.080]
Tumor Cells, Cultured [A11.251.860]
Cell Line, Tumor [A11.251.860.180]
A549 Cells [A11.251.860.180.080]
Epithelial Cells [A11.436]
A549 Cells [A11.436.054]

Below are MeSH descriptors whose meaning is related to "A549 Cells".

Below are MeSH descriptors whose meaning is more specific than "A549 Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "A549 Cells" by people in this website by year, and whether "A549 Cells" was a major or minor topic of these publications.

Bar chart showing 20 publications over 8 distinct years, with a maximum of 5 publications in 2018

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2016	2	2
2017	3	3
2018	5	5
2019	4	4
2020	1	1
2021	3	3
2022	1	1
2025	1	1

Below are the most recent publications written about "A549 Cells" by people in Profiles.

Kyawe PP, Liu P, Jiang Z, Bradley ES, Cicuto T, Trombly MI, Silverman N, Fitzgerald KA, McDougall WM, Wang JP. CRISPR editing of candidate host factors that impact influenza A virus infection. Microbiol Spectr. 2025 Mar 04; 13(3):e0262724.

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Chang CW, Parsi KM, Somasundaran M, Vanderleeden E, Liu P, Cruz J, Cousineau A, Finberg RW, Kurt-Jones EA. A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants. Viruses. 2022 06 23; 14(7).

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Koupenova M, Corkrey HA, Vitseva O, Tanriverdi K, Somasundaran M, Liu P, Soofi S, Bhandari R, Godwin M, Parsi KM, Cousineau A, Maehr R, Wang JP, Cameron SJ, Rade J, Finberg RW, Freedman JE. SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Circ Res. 2021 09 03; 129(6):631-646.

View in: PubMed
Chen Y, Lei X, Jiang Z, Fitzgerald KA. Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection. Proc Natl Acad Sci U S A. 2021 06 29; 118(26).

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A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection. Sci Immunol. 2021 05 18; 6(59).

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Takahashi N, Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP, Brugge JS. 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. Mol Cell. 2020 12 03; 80(5):828-844.e6.

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McDougall WM, Kandpal M, Perreira JM, Brass AL. Discovery of Zika Virus Dependency and Restriction Factors Using Flow-Based Arrayed CRISPR Screening for Identification of Targets (FACS-IT). Methods Mol Biol. 2020; 2142:215-234.

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Barasa L, Vemana HP, Surubhotla N, Ha SS, Kong J, Yong A, Croft JL, Dukhande VV, Yoganathan S. Synthesis and Biological Evaluation of Structurally Diverse Benzimidazole Scaffolds as Potential Chemotherapeutic Agents. Anticancer Agents Med Chem. 2020; 20(3):301-314.

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Lock M, Alvira M, Wilson J, Sena-Esteves M, Gao G. Detection Assay for Replication-Competent Adenovirus by Concentration Passage and Real-Time Quantitative Polymerase Chain Reaction (qPCR). Cold Spring Harb Protoc. 2019 12 02; 2019(12).

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Wu B, Yang X, Yan M. Synthesis and Structure-Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens. J Med Chem. 2019 09 12; 62(17):7751-7768.

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