LIM Domain Proteins

"LIM Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.

Descriptor ID	D060588
MeSH Number(s)	D12.776.512
Concept/Terms	LIM Domain Proteins LIM Domain Proteins

Below are MeSH descriptors whose meaning is more general than "LIM Domain Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
LIM Domain Proteins [D12.776.512]

Below are MeSH descriptors whose meaning is related to "LIM Domain Proteins".

Below are MeSH descriptors whose meaning is more specific than "LIM Domain Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "LIM Domain Proteins" by people in this website by year, and whether "LIM Domain Proteins" was a major or minor topic of these publications.

Bar chart showing 24 publications over 18 distinct years, with a maximum of 2 publications in 1997 and 1999 and 2002 and 2005 and 2006 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	2	2
1998	0	1	1
1999	0	2	2
2001	0	1	1
2002	0	2	2
2005	0	2	2
2006	0	2	2
2007	0	1	1
2008	0	1	1
2009	0	1	1
2010	0	1	1
2011	0	1	1
2013	0	1	1
2017	1	0	1
2018	0	1	1
2020	1	0	1
2024	2	0	2

Below are the most recent publications written about "LIM Domain Proteins" by people in Profiles.

O'Connor KW, Kishimoto K, Kuzma IO, Wagner KP, Selway JS, Roderick JE, Karna KK, Gallagher KM, Hu K, Liu H, Li R, Brehm MA, Zhu LJ, Curtis DJ, Tremblay CS, Kelliher MA. The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance. Leukemia. 2024 May; 38(5):951-962.

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Ray S, DeSilva C, Dasgupta I, Mana-Capelli S, Cruz-Calderon N, McCollum D. The ability of the LIMD1 and TRIP6 LIM domains to bind strained f-actin is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1. Cytoskeleton (Hoboken). 2024 Sep; 81(9-10):436-447.

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Brar N, Butzmann A, Kumar J, Peerani R, Morgan EA, Grigoriadis G, Kumar B, Tatarczuch RM, Warnke RA, Ohgami RS. LIM domain only 2 (LMO2) expression distinguishes T-lymphoblastic leukemia/lymphoma from indolent T-lymphoblastic proliferations. Histopathology. 2020 Dec; 77(6):984-988.

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Miao X, Liu W, Fan B, Lin H. Transcriptomic Heterogeneity of Alzheimer's Disease Associated with Lipid Genetic Risk. Neuromolecular Med. 2020 12; 22(4):534-541.

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Gharahkhani P, Burdon KP, Cooke Bailey JN, Hewitt AW, Law MH, Pasquale LR, Kang JH, Haines JL, Souzeau E, Zhou T, Siggs OM, Landers J, Awadalla M, Sharma S, Mills RA, Ridge B, Lynn D, Casson R, Graham SL, Goldberg I, White A, Healey PR, Grigg J, Lawlor M, Mitchell P, Ruddle J, Coote M, Walland M, Best S, Vincent A, Gale J, RadfordSmith G, Whiteman DC, Montgomery GW, Martin NG, Mackey DA, Wiggs JL, MacGregor S, Craig JE. Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Sci Rep. 2018 02 15; 8(1):3124.

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Dutta S, Mana-Capelli S, Paramasivam M, Dasgupta I, Cirka H, Billiar K, McCollum D. TRIP6 inhibits Hippo signaling in response to tension at adherens junctions. EMBO Rep. 2018 02; 19(2):337-350.

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Feeney SJ, McGrath MJ, Sriratana A, Gehrig SM, Lynch GS, D'Arcy CE, Price JT, McLean CA, Tupler R, Mitchell CA. FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1). PLoS One. 2015; 10(2):e0117665.

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Jiao B, Taniguchi-Ishigaki N, G?ng?r C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling. Mol Biol Cell. 2013 Oct; 24(19):3085-96.

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Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster JC, Kelliher MA. Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood. 2011 Aug 11; 118(6):1579-90.

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Draheim KM, Hermance N, Yang Y, Arous E, Calvo J, Kelliher MA. A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice. Oncogene. 2011 Mar 10; 30(10):1252-60.

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