"RNA Recognition Motif" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An approximately 80 amino acid RNA binding motif that consists of four anti-parallel surface beta sheets and two alpha helices arranged in a beta-alpha-beta-beta-alpha-beta configuration. One of the surface beta sheets interacts with two or three specific RNA bases. Interactions between additional sequences and the RNA, as well as within the RNA recognition motif increase the affinity and specificity of the protein-RNA interaction.
| Descriptor ID |
D000071377
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.869.500
|
| Concept/Terms |
RNA Recognition Motif- RNA Recognition Motif
- RNA Recognition Motifs
- Ribonucleoprotein Domain
- Ribonucleoprotein Domains
- RRM Motif
- RRM Motifs
|
Below are MeSH descriptors whose meaning is more general than "RNA Recognition Motif".
Below are MeSH descriptors whose meaning is more specific than "RNA Recognition Motif".
This graph shows the total number of publications written about "RNA Recognition Motif" by people in this website by year, and whether "RNA Recognition Motif" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "RNA Recognition Motif" by people in Profiles.
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Mackness BC, Morgan BR, Deveau LM, Kathuria SV, Zitzewitz JA, Massi F. A Hydrophobic Core Stabilizes the Residual Structure in the RRM2 Intermediate State of the ALS-linked Protein TDP-43. J Mol Biol. 2024 Nov 15; 436(22):168823.
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Tavella D, Zitzewitz JA, Massi F. Characterization of TDP-43 RRM2 Partially Folded States and Their Significance to ALS Pathogenesis. Biophys J. 2018 11 06; 115(9):1673-1680.