NF-KappaB Inhibitor alpha

"NF-KappaB Inhibitor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An I-kappa B protein that inhibits the activity of dimeric NF-KAPPA B P50-REL complexes, sequesters transcription factor NF-kappaB as an inactive complex in the cytoplasm; and prevents NF-kappaB nuclear translocation and DNA binding.

Descriptor ID	D000072000
MeSH Number(s)	D12.644.360.365.500 D12.776.260.420.500 D12.776.476.381.500 D12.776.930.326.500
Concept/Terms	NF-KappaB Inhibitor alpha NF-KappaB Inhibitor alpha Inhibitor alpha, NF-KappaB NF KappaB Inhibitor alpha alpha, NF-KappaB Inhibitor Major Histocompatibility Complex Enhancer-Binding Protein MAD3 Major Histocompatibility Complex Enhancer Binding Protein MAD3 IKappaB-alpha IKappaB alpha p40 Protein (IKappaB-alpha) I Kappa B-alpha Protein I Kappa B alpha Protein IKappaBalpha

Below are MeSH descriptors whose meaning is more general than "NF-KappaB Inhibitor alpha".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
I-kappa B Proteins [D12.644.360.365]
NF-KappaB Inhibitor alpha [D12.644.360.365.500]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
I-kappa B Proteins [D12.776.260.420]
NF-KappaB Inhibitor alpha [D12.776.260.420.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
I-kappa B Proteins [D12.776.476.381]
NF-KappaB Inhibitor alpha [D12.776.476.381.500]
Transcription Factors [D12.776.930]
I-kappa B Proteins [D12.776.930.326]
NF-KappaB Inhibitor alpha [D12.776.930.326.500]

Below are MeSH descriptors whose meaning is related to "NF-KappaB Inhibitor alpha".

Below are MeSH descriptors whose meaning is more specific than "NF-KappaB Inhibitor alpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-KappaB Inhibitor alpha" by people in this website by year, and whether "NF-KappaB Inhibitor alpha" was a major or minor topic of these publications.

Bar chart showing 22 publications over 13 distinct years, with a maximum of 4 publications in 2002

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1998	2	2
1999	2	2
2000	1	1
2001	1	1
2002	4	4
2003	1	1
2004	2	2
2005	2	2
2011	1	1
2012	1	1
2013	1	1
2015	3	3
2016	1	1

Below are the most recent publications written about "NF-KappaB Inhibitor alpha" by people in Profiles.

Poulos MG, Ramalingam P, Gutkin MC, Kleppe M, Ginsberg M, Crowley MJP, Elemento O, Levine RL, Rafii S, Kitajewski J, Greenblatt MB, Shim JH, Butler JM. Endothelial-specific inhibition of NF-?B enhances functional haematopoiesis. Nat Commun. 2016 12 21; 7:13829.

View in: PubMed
Zhou Q, Wang H, Schwartz DM, Stoffels M, Park YH, Zhang Y, Yang D, Demirkaya E, Takeuchi M, Tsai WL, Lyons JJ, Yu X, Ouyang C, Chen C, Chin DT, Zaal K, Chandrasekharappa SC, Hanson EP, Yu Z, Mullikin JC, Hasni SA, Wertz IE, Ombrello AK, Stone DL, Hoffmann P, Jones A, Barham BK, Leavis HL, van Royen-Kerkof A, Sibley C, Batu ED, G?l A, Siegel RM, Boehm M, Milner JD, Ozen S, Gadina M, Chae J, Laxer RM, Kastner DL, Aksentijevich I. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016 01; 48(1):67-73.

View in: PubMed
Mak P, Li J, Samanta S, Mercurio AM. ER? regulation of NF-kB activation in prostate cancer is mediated by HIF-1. Oncotarget. 2015 Nov 24; 6(37):40247-54.

View in: PubMed
Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts. J Exp Med. 2015 Jul 27; 212(8):1283-301.

View in: PubMed
Park EJ, Shen L, Sun D, Pezzuto JM. Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J Nat Prod. 2014 Mar 28; 77(3):527-35.

View in: PubMed
Kim JK. Endothelial nuclear factor ?B in obesity and aging: is endothelial nuclear factor ?B a master regulator of inflammation and insulin resistance? Circulation. 2012 Mar 06; 125(9):1081-3.

View in: PubMed
Balasubramanian S, Fan M, Messmer-Blust AF, Yang CH, Trendel JA, Jeyaratnam JA, Pfeffer LM, Vestal DJ. The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein. J Biol Chem. 2011 Jun 03; 286(22):20054-64.

View in: PubMed
Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O'Keefe RJ. Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C310-20.

View in: PubMed
Chakrabarti S, Blair P, Wu C, Freedman JE. Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects. J Cardiovasc Pharmacol. 2007 Oct; 50(4):449-57.

View in: PubMed
Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. J Cell Biochem. 2005 Dec 15; 96(6):1262-73.

View in: PubMed

People

Explore

Similar Concepts

Top Journals