MAP Kinase Kinase 7

"MAP Kinase Kinase 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to CYTOKINES.

Descriptor ID	D048688
MeSH Number(s)	D08.811.913.696.620.682.700.565.700 D08.811.913.696.620.682.725.200.700 D12.644.360.440.700 D12.776.476.440.700
Concept/Terms	MAP Kinase Kinase 7 MAP Kinase Kinase 7 PRKMK7 Mitogen-Activated Protein Kinase Kinase 7 Mitogen Activated Protein Kinase Kinase 7 MAPKK7 Protein Kinase Protein Kinase, MAPKK7 MEK7 Protein Kinase Protein Kinase, MEK7 SKK4 Protein Kinase Protein Kinase, SKK4 JNK-Activating Kinase 2 JNK Activating Kinase 2 SEK2 Protein Kinase Protein Kinase, SEK2

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 7".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
MAP Kinase Kinase 7 [D08.811.913.696.620.682.700.565.700]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
MAP Kinase Kinase 7 [D08.811.913.696.620.682.725.200.700]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]
MAP Kinase Kinase 7 [D12.644.360.440.700]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]
MAP Kinase Kinase 7 [D12.776.476.440.700]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase 7".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 7".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase 7" by people in this website by year, and whether "MAP Kinase Kinase 7" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2004 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2004	0	2	2
2005	0	1	1
2007	0	1	1
2011	1	0	1
2013	0	1	1
2014	1	0	1
2018	1	1	2
2019	0	1	1
2021	1	0	1

Below are the most recent publications written about "MAP Kinase Kinase 7" by people in Profiles.

Caliz AD, Yoo HJ, Vertii A, Dolan AC, Tournier C, Davis RJ, Keaney JF, Kant S. Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice. Int J Mol Sci. 2021 Aug 29; 22(17).

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Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ. JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Nat Commun. 2019 05 14; 10(1):2148.

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Shraga A, Olshvang E, Davidzohn N, Khoshkenar P, Germain N, Shurrush K, Carvalho S, Avram L, Albeck S, Unger T, Lefker B, Subramanyam C, Hudkins RL, Mitchell A, Shulman Z, Kinoshita T, London N. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chem Biol. 2019 01 17; 26(1):98-108.e5.

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Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, ?stevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun. 2018 08 30; 9(1):3524.

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Davies CC, Harvey E, McMahon RF, Finegan KG, Connor F, Davis RJ, Tuveson DA, Tournier C. Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Res. 2014 Jun 15; 74(12):3344-56.

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You H, Padmashali RM, Ranganathan A, Lei P, Girnius N, Davis RJ, Andreadis ST. JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues. J Cell Sci. 2013 Jun 15; 126(Pt 12):2718-29.

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Liu W, Zi M, Chi H, Jin J, Prehar S, Neyses L, Cartwright EJ, Flavell RA, Davis RJ, Wang X. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. J Mol Cell Cardiol. 2011 Apr; 50(4):702-11.

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Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell. 2007 Aug 03; 27(3):498-508.

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Kelkar N, Standen CL, Davis RJ. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol. 2005 Apr; 25(7):2733-43.

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Morton S, Davis RJ, Cohen P. Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. FEBS Lett. 2004 Aug 13; 572(1-3):177-83.

View in: PubMed

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