"Presenilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
Below are MeSH descriptors whose meaning is more general than "Presenilins".
Below are MeSH descriptors whose meaning is more specific than "Presenilins".
This graph shows the total number of publications written about "Presenilins" by people in this website by year, and whether "Presenilins" was a major or minor topic of these publications.
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Below are the most recent publications written about "Presenilins" by people in Profiles.
Aliseychik MP, Andreeva TV, Rogaev EI. Immunogenetic Factors of Neurodegenerative Diseases: The Role of HLA Class II. Biochemistry (Mosc). 2018 Sep; 83(9):1104-1116.
Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS. A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J Neurosci. 2012 Jun 20; 32(25):8633-48.
Grigorenko AP, Rogaev EI. [Molecular basics of Alzheimer's disease]. Mol Biol (Mosk). 2007 Mar-Apr; 41(2):331-45.
Boulianne GL, Livne-Bar I, Humphreys JM, Liang Y, Lin C, Rogaev E, St George-Hyslop P. Cloning and characterization of the Drosophila presenilin homologue. Neuroreport. 1997 Mar 03; 8(4):1025-9.