CCAAT-Enhancer-Binding Proteins

"CCAAT-Enhancer-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.

Descriptor ID	D022762
MeSH Number(s)	D12.776.260.108.124 D12.776.660.167 D12.776.930.127.124
Concept/Terms	CCAAT-Enhancer-Binding Proteins CCAAT-Enhancer-Binding Proteins CCAAT Enhancer Binding Proteins CAAT-Enhancer Binding Protein Binding Protein, CAAT-Enhancer CAAT Enhancer Binding Protein CCAAT-Enhancer-Binding Protein CCAAT Enhancer Binding Protein C-EBP Protein C EBP Protein C-EBP Nuclear Protein C EBP Nuclear Protein Nuclear Protein, C-EBP CAAT-Enhancer-Binding Proteins CAAT Enhancer Binding Proteins C-EBP Proteins C EBP Proteins CCAAT Sequence-Specific DNA-Binding Proteins CCAAT Sequence Specific DNA Binding Proteins Nuclear Protein C-EBP C-EBP, Nuclear Protein Nuclear Protein C EBP

Below are MeSH descriptors whose meaning is more general than "CCAAT-Enhancer-Binding Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
CCAAT-Enhancer-Binding Proteins [D12.776.260.108.124]
Nuclear Proteins [D12.776.660]
CCAAT-Enhancer-Binding Proteins [D12.776.660.167]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
CCAAT-Enhancer-Binding Proteins [D12.776.930.127.124]

Below are MeSH descriptors whose meaning is related to "CCAAT-Enhancer-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "CCAAT-Enhancer-Binding Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CCAAT-Enhancer-Binding Proteins" by people in this website by year, and whether "CCAAT-Enhancer-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 24 publications over 18 distinct years, with a maximum of 3 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	1	0	1
1997	0	2	2
1998	1	0	1
1999	0	1	1
2000	1	1	2
2001	1	0	1
2003	2	0	2
2004	0	1	1
2005	0	1	1
2006	1	0	1
2009	1	0	1
2010	1	0	1
2011	0	1	1
2012	0	2	2
2015	1	0	1
2016	1	2	3
2019	0	1	1

Below are the most recent publications written about "CCAAT-Enhancer-Binding Proteins" by people in Profiles.

Rushton MD, Saunderson EA, Patani H, Green MR, Ficz G. An shRNA kinase screen identifies regulators of UHRF1 stability and activity in mouse embryonic stem cells. Epigenetics. 2022 12; 17(12):1590-1607.

View in: PubMed
Zhao P, Wang H, Wang H, Dang Y, Luo L, Li S, Shi Y, Wang L, Wang S, Mager J, Zhang K. Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development. Epigenetics. 2020 04; 15(4):369-385.

View in: PubMed
Malu K, Garhwal R, Pelletier MG, Gotur D, Halene S, Zwerger M, Yang ZF, Rosmarin AG, Gaines P. Cooperative Activity of GABP with PU.1 or C/EBPe Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation. J Immunol. 2016 08 01; 197(3):910-22.

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LeBlanc SE, Wu Q, Lamba P, Sif S, Imbalzano AN. Promoter-enhancer looping at the PPAR?2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Res. 2016 06 20; 44(11):5133-47.

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Reddy KC, Dunbar TL, Nargund AM, Haynes CM, Troemel ER. The C.?elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity. Cell Rep. 2016 Feb 23; 14(7):1581-1589.

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Bauer RC, Sasaki M, Cohen DM, Cui J, Smith MA, Yenilmez BO, Steger DJ, Rader DJ. Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPa. J Clin Invest. 2015 Oct 01; 125(10):3809-18.

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Pan D, Mao C, Zou T, Yao AY, Cooper MP, Boyartchuk V, Wang YX. The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. PLoS Genet. 2012; 8(6):e1002761.

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LeBlanc SE, Konda S, Wu Q, Hu YJ, Oslowski CM, Sif S, Imbalzano AN. Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor ?2 (PPAR?2) and its target genes during adipogenesis. Mol Endocrinol. 2012 Apr; 26(4):583-97.

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Siegelin MD, Dohi T, Raskett CM, Orlowski GM, Powers CM, Gilbert CA, Ross AH, Plescia J, Altieri DC. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011 Apr; 121(4):1349-60.

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Wu Q, Saunders RA, Szkudlarek-Mikho M, Serna Ide L, Chin KV. The obesity-associated Fto gene is a transcriptional coactivator. Biochem Biophys Res Commun. 2010 Oct 22; 401(3):390-5.

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