Tumor Suppressor p53-Binding Protein 1

"Tumor Suppressor p53-Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.

Descriptor ID	D000071857
MeSH Number(s)	D12.776.260.805 D12.776.660.235.850 D12.776.664.235.950
Concept/Terms	Tumor Suppressor p53-Binding Protein 1 Tumor Suppressor p53-Binding Protein 1 Tumor Suppressor p53 Binding Protein 1 TP53BP1 Protein p202 Protein Tumor Protein p53-Binding Protein, 1 Tumor Protein p53 Binding Protein, 1 53BP1 Protein

Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor p53-Binding Protein 1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Tumor Suppressor p53-Binding Protein 1 [D12.776.260.805]
Nuclear Proteins [D12.776.660]
Chromosomal Proteins, Non-Histone [D12.776.660.235]
Tumor Suppressor p53-Binding Protein 1 [D12.776.660.235.850]
Nucleoproteins [D12.776.664]
Chromosomal Proteins, Non-Histone [D12.776.664.235]
Tumor Suppressor p53-Binding Protein 1 [D12.776.664.235.950]

Below are MeSH descriptors whose meaning is related to "Tumor Suppressor p53-Binding Protein 1".

Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor p53-Binding Protein 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tumor Suppressor p53-Binding Protein 1" by people in this website by year, and whether "Tumor Suppressor p53-Binding Protein 1" was a major or minor topic of these publications.

Bar chart showing 7 publications over 5 distinct years, with a maximum of 3 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2006	0	1	1
2014	0	1	1
2016	1	0	1
2021	1	2	3

Below are the most recent publications written about "Tumor Suppressor p53-Binding Protein 1" by people in Profiles.

Paes Dias M, Tripathi V, van der Heijden I, Cong K, Manolika EM, Bhin J, Gogola E, Galanos P, Annunziato S, Lieftink C, And?jar-S?nchez M, Chakrabarty S, Smith GCM, van de Ven M, Beijersbergen RL, Bartkova J, Rottenberg S, Cantor S, Bartek J, Ray Chaudhuri A, Jonkers J. Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps. Mol Cell. 2021 11 18; 81(22):4692-4708.e9.

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Garwain O, Sun X, Iyer DR, Li R, Zhu LJ, Kaufman PD. The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damage. Proc Natl Acad Sci U S A. 2021 08 10; 118(32).

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Cong K, Peng M, Kousholt AN, Lee WTC, Lee S, Nayak S, Krais J, VanderVere-Carozza PS, Pawelczak KS, Calvo J, Panzarino NJ, Turchi JJ, Johnson N, Jonkers J, Rothenberg E, Cantor SB. Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency. Mol Cell. 2021 08 05; 81(15):3128-3144.e7.

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Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ. A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. J Cell Biol. 2016 07 18; 214(2):143-53.

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Khair L, Guikema JE, Linehan EK, Ucher AJ, Leus NG, Ogilvie C, Lou Z, Schrader CE, Stavnezer J. ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. J Immunol. 2014 May 15; 192(10):4887-96.

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Frame FM, Rogoff HA, Pickering MT, Cress WD, Kowalik TF. E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts. Oncogene. 2006 Jun 01; 25(23):3258-66.

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Joo WS, Jeffrey PD, Cantor SB, Finnin MS, Livingston DM, Pavletich NP. Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev. 2002 Mar 01; 16(5):583-93.

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