Deubiquitinating Enzyme CYLD
"Deubiquitinating Enzyme CYLD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
| Descriptor ID |
D000074749
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| MeSH Number(s) |
D08.811.037.375 D12.776.624.776.482
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| Concept/Terms |
Deubiquitinating Enzyme CYLD- Deubiquitinating Enzyme CYLD
- CYLD, Deubiquitinating Enzyme
- Cylindromatosis Protein
- Deubiquitinating Enzyme Cylindromatosis
- Cylindromatosis, Deubiquitinating Enzyme
- CYLD Protein
|
Below are MeSH descriptors whose meaning is more general than "Deubiquitinating Enzyme CYLD".
Below are MeSH descriptors whose meaning is more specific than "Deubiquitinating Enzyme CYLD".
This graph shows the total number of publications written about "Deubiquitinating Enzyme CYLD" by people in this website by year, and whether "Deubiquitinating Enzyme CYLD" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Deubiquitinating Enzyme CYLD" by people in Profiles.
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Williams EA, Montesion M, Alexander BM, Ramkissoon SH, Elvin JA, Ross JS, Williams KJ, Glomski K, Bledsoe JR, Tse JY, Mochel MC. CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features. Mod Pathol. 2021 02; 34(2):358-370.
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Dobson-Stone C, Hallupp M, Shahheydari H, Ragagnin AMG, Chatterton Z, Carew-Jones F, Shepherd CE, Stefen H, Paric E, Fath T, Thompson EM, Blumbergs P, Short CL, Field CD, Panegyres PK, Hecker J, Nicholson G, Shaw AD, Fullerton JM, Luty AA, Schofield PR, Brooks WS, Rajan N, Bennett MF, Bahlo M, Landers JE, Piguet O, Hodges JR, Halliday GM, Topp SD, Smith BN, Shaw CE, McCann E, Fifita JA, Williams KL, Atkin JD, Blair IP, Kwok JB. CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis. Brain. 2020 03 01; 143(3):783-799.
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Legarda D, Justus SJ, Ang RL, Rikhi N, Li W, Moran TM, Zhang J, Mizoguchi E, Zelic M, Kelliher MA, Blander JM, Ting AT. CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN. Cell Rep. 2016 06 14; 15(11):2449-61.
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Moquin DM, McQuade T, Chan FK. CYLD deubiquitinates RIP1 in the TNFa-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One. 2013; 8(10):e76841.