F-Box-WD Repeat-Containing Protein 7
"F-Box-WD Repeat-Containing Protein 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
| Descriptor ID |
D000073979
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| MeSH Number(s) |
D08.811.464.938.750.750.750 D12.776.157.169.750 D12.776.167.242
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| Concept/Terms |
F-Box-WD Repeat-Containing Protein 7- F-Box-WD Repeat-Containing Protein 7
- F Box WD Repeat Containing Protein 7
- F-Box and WD-40 Domain-Containing Protein 7
- F Box and WD 40 Domain Containing Protein 7
- FBXW7 Protein
|
Below are MeSH descriptors whose meaning is more general than "F-Box-WD Repeat-Containing Protein 7".
Below are MeSH descriptors whose meaning is more specific than "F-Box-WD Repeat-Containing Protein 7".
This graph shows the total number of publications written about "F-Box-WD Repeat-Containing Protein 7" by people in this website by year, and whether "F-Box-WD Repeat-Containing Protein 7" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "F-Box-WD Repeat-Containing Protein 7" by people in Profiles.
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Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013 Jul 29; 210(8):1545-57.
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Wei P, Pan D, Mao C, Wang YX. RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1a and modulates brown fat cell metabolism. Mol Cell Biol. 2012 Jan; 32(2):266-75.