Smad3 Protein

"Smad3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.

Descriptor ID	D051900
MeSH Number(s)	D12.644.360.024.334.500.300 D12.776.157.057.170.500.300 D12.776.260.713.500.300 D12.776.476.024.428.500.300 D12.776.744.741.875 D12.776.930.806.500.300
Concept/Terms	Smad3 Protein Smad3 Protein Madh3 Protein

Below are MeSH descriptors whose meaning is more general than "Smad3 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Smad Proteins [D12.644.360.024.334]
Smad Proteins, Receptor-Regulated [D12.644.360.024.334.500]
Smad3 Protein [D12.644.360.024.334.500.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Smad Proteins [D12.776.157.057.170]
Smad Proteins, Receptor-Regulated [D12.776.157.057.170.500]
Smad3 Protein [D12.776.157.057.170.500.300]
DNA-Binding Proteins [D12.776.260]
Smad Proteins [D12.776.260.713]
Smad Proteins, Receptor-Regulated [D12.776.260.713.500]
Smad3 Protein [D12.776.260.713.500.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Smad Proteins [D12.776.476.024.428]
Smad Proteins, Receptor-Regulated [D12.776.476.024.428.500]
Smad3 Protein [D12.776.476.024.428.500.300]
Phosphoproteins [D12.776.744]
Smad Proteins, Receptor-Regulated [D12.776.744.741]
Smad3 Protein [D12.776.744.741.875]
Transcription Factors [D12.776.930]
Smad Proteins [D12.776.930.806]
Smad Proteins, Receptor-Regulated [D12.776.930.806.500]
Smad3 Protein [D12.776.930.806.500.300]

Below are MeSH descriptors whose meaning is related to "Smad3 Protein".

Below are MeSH descriptors whose meaning is more specific than "Smad3 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Smad3 Protein" by people in this website by year, and whether "Smad3 Protein" was a major or minor topic of these publications.

Bar chart showing 14 publications over 12 distinct years, with a maximum of 2 publications in 2009 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2004	0	1	1
2008	0	1	1
2009	1	1	2
2011	0	1	1
2012	2	0	2
2013	1	0	1
2014	1	0	1
2015	0	1	1
2016	1	0	1
2017	0	1	1

Below are the most recent publications written about "Smad3 Protein" by people in Profiles.

Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-P?rez JA, Fazzio TG. KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell Rep. 2017 04 25; 19(4):671-679.

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Daneshvar K, Pondick JV, Kim BM, Zhou C, York SR, Macklin JA, Abualteen A, Tan B, Sigova AA, Marcho C, Tremblay KD, Mager J, Choi MY, Mullen AC. DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells. Cell Rep. 2016 10 04; 17(2):353-365.

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Fan J, Yang MX, Ouyang Q, Fu D, Xu Z, Liu X, Mino-Kenudson M, Geng J, Tang F. Phosphatase PPM1A is a novel prognostic marker in pancreatic ductal adenocarcinoma. Hum Pathol. 2016 09; 55:151-8.

View in: PubMed
Csak T, Bala S, Lippai D, Kodys K, Catalano D, Iracheta-Vellve A, Szabo G. MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. PLoS One. 2015; 10(6):e0129251.

View in: PubMed
Mullen AC. Hippo tips the TGF-? scale in favor of pluripotency. Cell Stem Cell. 2014 Jan 02; 14(1):6-8.

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Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med. 2013 Jul; 19(7):810-1.

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Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ. Ski inhibits TGF-?/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. J Cell Biochem. 2012 Jun; 113(6):2156-66.

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Di X, Andrews DM, Tucker CJ, Yu L, Moore AB, Zheng X, Castro L, Hermon T, Xiao H, Dixon D. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-? pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30; 44(4):281-92.

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Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012 Feb 05; 18(3):396-404.

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Mullen AC, Orlando DA, Newman JJ, Lov?n J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-? signaling. Cell. 2011 Oct 28; 147(3):565-76.

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