Serpins

"Serpins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES.

Descriptor ID	D015843
MeSH Number(s)	D12.644.861 D12.776.872 D27.505.519.389.745.800.675
Concept/Terms	Serpins Serpins Serpin Protease Inhibitors Inhibitors, Serpin Protease Protease Inhibitors, Serpin Serpin Peptidase Inhibitors Inhibitors, Serpin Peptidase Peptidase Inhibitors, Serpin Serpin Superfamily Serpin Superfamily Superfamily, Serpin

Below are MeSH descriptors whose meaning is more general than "Serpins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Serpins [D12.644.861]
Proteins [D12.776]
Serpins [D12.776.872]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Protease Inhibitors [D27.505.519.389.745]
Serine Proteinase Inhibitors [D27.505.519.389.745.800]
Serpins [D27.505.519.389.745.800.675]

Below are MeSH descriptors whose meaning is related to "Serpins".

Below are MeSH descriptors whose meaning is more specific than "Serpins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Serpins" by people in this website by year, and whether "Serpins" was a major or minor topic of these publications.

Bar chart showing 16 publications over 13 distinct years, with a maximum of 2 publications in 2015 and 2017 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	1	0	1
2004	1	0	1
2006	1	0	1
2008	1	0	1
2009	1	0	1
2014	1	0	1
2015	1	1	2
2016	1	0	1
2017	0	2	2
2018	0	1	1
2019	1	0	1
2020	2	0	2

Below are the most recent publications written about "Serpins" by people in Profiles.

Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020 11 25; 183(5):1219-1233.e18.

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Muhammad F, Avalos PN, Mursalin MH, Ma JX, Callegan MC, Lee DJ. Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells. Front Immunol. 2020; 11:975.

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Adams BM, Ke H, Gierasch LM, Gershenson A, Hebert DN. Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control. J Biol Chem. 2019 12 13; 294(50):18992-19011.

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Karthikkeyan G, Nareshkumar RN, Aberami S, Sulochana KN, Vedantham S, Coral K. Hyperglycemia induced early growth response-1 regulates vascular dysfunction in human retinal endothelial cells. Microvasc Res. 2018 05; 117:37-43.

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Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21).

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Lin L, Rodrigues FSLM, Kary C, Contet A, Logan M, Baxter RHG, Wood W, Baehrecke EH. Complement-Related Regulates Autophagy in Neighboring Cells. Cell. 2017 Jun 29; 170(1):158-171.e8.

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Zand S, Buzney E, Duncan LM, Dadras SS. Heterogeneity of Metastatic Melanoma: ?Correlation of MITF With Its Transcriptional Targets MLSN1, PEDF, HMB-45, and MART-1. Am J Clin Pathol. 2016 Sep; 146(3):353-60.

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Hou L, Cooley J, Swanson R, Ong PC, Pike RN, Bogyo M, Olson ST, Remold-O'Donnell E. The protease cathepsin L regulates Th17 cell differentiation. J Autoimmun. 2015 Dec; 65:56-63.

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Dadras SS, Lin RJ, Fisher DE. Authors' Reply. Am J Pathol. 2015 Jul; 185(7):2070.

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Dadras SS, Lin RJ, Razavi G, Kawakami A, Du J, Feige E, Milner DA, Loda MF, Granter SR, Detmar M, Widlund HR, Horstmann MA, Fisher DE. A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression. Am J Pathol. 2015 Jan; 185(1):252-65.

View in: PubMed

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