Serpins

"Serpins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES.

Descriptor ID	D015843
MeSH Number(s)	D12.644.861 D12.776.872 D27.505.519.389.745.800.675
Concept/Terms	Serpins Serpins Serpin Protease Inhibitors Inhibitors, Serpin Protease Protease Inhibitors, Serpin Serpin Peptidase Inhibitors Inhibitors, Serpin Peptidase Peptidase Inhibitors, Serpin Serpin Superfamily Serpin Superfamily Superfamily, Serpin

Below are MeSH descriptors whose meaning is more general than "Serpins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Serpins [D12.644.861]
Proteins [D12.776]
Serpins [D12.776.872]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Protease Inhibitors [D27.505.519.389.745]
Serine Proteinase Inhibitors [D27.505.519.389.745.800]
Serpins [D27.505.519.389.745.800.675]

Below are MeSH descriptors whose meaning is related to "Serpins".

Below are MeSH descriptors whose meaning is more specific than "Serpins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Serpins" by people in this website by year, and whether "Serpins" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2008	1	0	1
2009	1	0	1
2015	0	1	1
2017	0	1	1
2018	0	1	1
2019	1	0	1
2020	2	0	2

Below are the most recent publications written about "Serpins" by people in Profiles.

Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020 11 25; 183(5):1219-1233.e18.

View in: PubMed
Muhammad F, Avalos PN, Mursalin MH, Ma JX, Callegan MC, Lee DJ. Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells. Front Immunol. 2020; 11:975.

View in: PubMed
Adams BM, Ke H, Gierasch LM, Gershenson A, Hebert DN. Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control. J Biol Chem. 2019 12 13; 294(50):18992-19011.

View in: PubMed
Karthikkeyan G, Nareshkumar RN, Aberami S, Sulochana KN, Vedantham S, Coral K. Hyperglycemia induced early growth response-1 regulates vascular dysfunction in human retinal endothelial cells. Microvasc Res. 2018 05; 117:37-43.

View in: PubMed
Lin L, Rodrigues FSLM, Kary C, Contet A, Logan M, Baxter RHG, Wood W, Baehrecke EH. Complement-Related Regulates Autophagy in Neighboring Cells. Cell. 2017 Jun 29; 170(1):158-171.e8.

View in: PubMed
Hou L, Cooley J, Swanson R, Ong PC, Pike RN, Bogyo M, Olson ST, Remold-O'Donnell E. The protease cathepsin L regulates Th17 cell differentiation. J Autoimmun. 2015 Dec; 65:56-63.

View in: PubMed
Ahmad ST, Sweeney ST, Lee JA, Sweeney NT, Gao FB. Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12168-73.

View in: PubMed
Plunkett BA, Fitchev P, Doll JA, Gerber SE, Cornwell M, Greenstein EP, Crawford SE. Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths. Reprod Biol. 2008 Jul; 8(2):107-20.

View in: PubMed
DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celed?n J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.

View in: PubMed

People

Explore

Similar Concepts

Top Journals