Interferon Regulatory Factor-1

"Interferon Regulatory Factor-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA. It functions as a transcriptional activator for the INTERFERON TYPE I genes.

Descriptor ID	D050856
MeSH Number(s)	D12.644.360.024.302.124 D12.776.157.057.050.124 D12.776.260.108.374 D12.776.260.504.124 D12.776.476.024.385.124 D12.776.930.127.374 D12.776.930.332.124
Concept/Terms	Interferon Regulatory Factor-1 Interferon Regulatory Factor-1 Interferon Regulatory Factor 1 IRF-1 Protein IRF 1 Protein IREBF1 Transcription Factor Transcription Factor, IREBF1 IREBF1 Protein IRF-1 Transcription Factor Factor, IRF-1 Transcription IRF 1 Transcription Factor Transcription Factor, IRF-1 ISGF1 Transcription Factor Factor, ISGF1 Transcription Transcription Factor, ISGF1 Interferon-Stimulated Gene Factor 1 Interferon Stimulated Gene Factor 1 MyD32 Protein

Below are MeSH descriptors whose meaning is more general than "Interferon Regulatory Factor-1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Interferon Regulatory Factors [D12.644.360.024.302]
Interferon Regulatory Factor-1 [D12.644.360.024.302.124]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Interferon Regulatory Factors [D12.776.157.057.050]
Interferon Regulatory Factor-1 [D12.776.157.057.050.124]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Interferon Regulatory Factor-1 [D12.776.260.108.374]
Interferon Regulatory Factors [D12.776.260.504]
Interferon Regulatory Factor-1 [D12.776.260.504.124]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Interferon Regulatory Factors [D12.776.476.024.385]
Interferon Regulatory Factor-1 [D12.776.476.024.385.124]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
Interferon Regulatory Factor-1 [D12.776.930.127.374]
Interferon Regulatory Factors [D12.776.930.332]
Interferon Regulatory Factor-1 [D12.776.930.332.124]

Below are MeSH descriptors whose meaning is related to "Interferon Regulatory Factor-1".

Below are MeSH descriptors whose meaning is more specific than "Interferon Regulatory Factor-1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interferon Regulatory Factor-1" by people in this website by year, and whether "Interferon Regulatory Factor-1" was a major or minor topic of these publications.

Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 2003 and 2005 and 2014 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2005	0	1	1
2014	0	1	1
2015	1	0	1

Below are the most recent publications written about "Interferon Regulatory Factor-1" by people in Profiles.

Annibali V, Umeton R, Palermo A, Severa M, Etna MP, Giglio S, Romano S, Ferraldeschi M, Buscarinu MC, Vecchione A, Annese A, Policano C, Mechelli R, Pizzolato Umeton R, Fornasiero A, Angelini DF, Guerrera G, Battistini L, Coccia EM, Salvetti M, Ristori G. Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients. J Neuroimmunol. 2018 11 15; 324:165-171.

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Fitzgerald KA, Rathinam VA. GBPs take AIM at Francisella. Nat Immunol. 2015 May; 16(5):443-4.

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Nilsen NJ, Vladimer GI, Stenvik J, Orning MP, Zeid-Kilani MV, Bugge M, Bergstroem B, Conlon J, Husebye H, Hise AG, Fitzgerald KA, Espevik T, Lien E. A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling. J Biol Chem. 2015 Feb 06; 290(6):3209-22.

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Stefan M, Jacobson EM, Huber AK, Greenberg DA, Li CW, Skrabanek L, Conception E, Fadlalla M, Ho K, Tomer Y. Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism. J Biol Chem. 2011 Sep 09; 286(36):31168-79.

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Park IK, Shultz LD, Letterio JJ, Gorham JD. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol. 2005 Nov 01; 175(9):5666-74.

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Hoshiya Y, Gupta V, Kawakubo H, Brachtel E, Carey JL, Sasur L, Scott A, Donahoe PK, Maheswaran S. Mullerian inhibiting substance promotes interferon gamma-induced gene expression and apoptosis in breast cancer cells. J Biol Chem. 2003 Dec 19; 278(51):51703-12.

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Xie RL, Gupta S, Miele A, Shiffman D, Stein JL, Stein GS, van Wijnen AJ. The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter. J Biol Chem. 2003 Jul 18; 278(29):26589-96.

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Aziz F, van Wijnen AJ, Vaughan PS, Wu S, Shakoori AR, Lian JB, Soprano KJ, Stein JL, Stein GS. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. Mol Biol Rep. 1998 Jan; 25(1):1-12.

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