"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.
| Descriptor ID |
D064113
|
| MeSH Number(s) |
G05.308.203.374.394
|
| Concept/Terms |
CRISPR-Cas Systems- CRISPR-Cas Systems
- CRISPR Cas Systems
- CRISPR-Cas System
- System, CRISPR-Cas
- Systems, CRISPR-Cas
|
Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".
Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".
This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 6 | 1 | 7 |
| 2015 | 8 | 3 | 11 |
| 2016 | 11 | 11 | 22 |
| 2017 | 16 | 6 | 22 |
| 2018 | 14 | 8 | 22 |
| 2019 | 12 | 17 | 29 |
| 2020 | 8 | 6 | 14 |
| 2021 | 8 | 13 | 21 |
| 2022 | 3 | 7 | 10 |
| 2023 | 8 | 7 | 15 |
| 2024 | 3 | 7 | 10 |
| 2025 | 4 | 6 | 10 |
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Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.
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Hanlon MB, Shohet JM, Wolfe SA. Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death. Nat Commun. 2025 Jun 02; 16(1):5126.
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Bourgade B, Xie H, Lindblad P, Stensj? K. Development of a CRISPR activation system for targeted gene upregulation in Synechocystis sp. PCC 6803. Commun Biol. 2025 May 21; 8(1):772.
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Xie H, Bourgade B, Stensj? K, Lindblad P. dCas12a-mediated CRISPR interference for multiplex gene repression in cyanobacteria for enhanced isobutanol and 3-methyl-1-butanol production. Microb Cell Fact. 2025 May 13; 24(1):104.
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Nayyab S, Gervasi MG, Tourzani DA, Shamailova Y, Akizawa H, Taghavi M, Cui W, Fissore R, Salicioni AM, Georg GI, Snyder E, Visconti PE. Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception. Biomolecules. 2025 Apr 18; 15(4).
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Yin X, Wang R, Thackeray A, Baehrecke EH, Alkema MJ. VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegans. G3 (Bethesda). 2025 Apr 17; 15(4).
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Simwela NV, Jaecklein E, Sassetti CM, Russell DG. Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis. Elife. 2025 Mar 13; 13.
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Banday S, Mishra AK, Rashid R, Ye T, Ali A, Li J, Yustein JT, Kelliher MA, Zhu LJ, Deibler SK, Malonia SK, Green MR. The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma. Nat Commun. 2025 Feb 02; 16(1):1267.
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Kyawe PP, Liu P, Jiang Z, Bradley ES, Cicuto T, Trombly MI, Silverman N, Fitzgerald KA, McDougall WM, Wang JP. CRISPR editing of candidate host factors that impact influenza A virus infection. Microbiol Spectr. 2025 Mar 04; 13(3):e0262724.
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Whalen JM, Earley J, Wisniewski C, Mercurio AM, Cantor SB. Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability. Nat Cancer. 2025 Feb; 6(2):278-291.
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Lee JM, Zeng J, Liu P, Nguyen MA, Suchenski Loustaunau D, Bauer DE, Kurt Yilmaz N, Wolfe SA, Schiffer CA. Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets. Nucleic Acids Res. 2025 Jan 07; 53(1).