CRISPR-Cas Systems

"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.

Descriptor ID	D064113
MeSH Number(s)	G05.308.203.374.394
Concept/Terms	CRISPR-Cas Systems CRISPR-Cas Systems CRISPR Cas Systems CRISPR-Cas System System, CRISPR-Cas Systems, CRISPR-Cas

Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]
CRISPR-Cas Systems [G05.308.203.374.394]

Below are MeSH descriptors whose meaning is related to "CRISPR-Cas Systems".

Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.

Bar chart showing 140 publications over 9 distinct years, with a maximum of 30 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	6	1	7
2015	8	3	11
2016	7	11	18
2017	12	5	17
2018	14	8	22
2019	12	18	30
2020	8	6	14
2021	7	12	19
2022	1	1	2

Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.

Simkin D, Papakis V, Bustos BI, Ambrosi CM, Ryan SJ, Baru V, Williams LA, Dempsey GT, McManus OB, Landers JE, Lubbe SJ, George AL, Kiskinis E. Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls. Stem Cell Reports. 2022 Apr 12; 17(4):993-1008.

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Liang SQ, Liu P, Smith JL, Mintzer E, Maitland S, Dong X, Yang Q, Lee J, Haynes CM, Zhu LJ, Watts JK, Sontheimer EJ, Wolfe SA, Xue W. Genome-wide detection of CRISPR editing in vivo using GUIDE-tag. Nat Commun. 2022 01 21; 13(1):437.

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Keeler AM. Immune Responses to Adeno-Associated Virus-Mediated CRISPR Therapy. Hum Gene Ther. 2021 Dec; 32(23-24):1430-1432.

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Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP. CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease. Nat Commun. 2021 11 26; 12(1):6931.

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Kiritsy MC, Ankley LM, Trombley J, Huizinga GP, Lord AE, Orning P, Elling R, Fitzgerald KA, Olive AJ. A genetic screen in macrophages identifies new regulators of IFN?-inducible MHCII that contribute to T cell activation. Elife. 2021 11 08; 10.

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Liang SQ, Walkey CJ, Martinez AE, Su Q, Dickinson ME, Wang D, Lagor WR, Heaney JD, Gao G, Xue W. AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway. Mol Ther. 2022 01 05; 30(1):238-243.

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Jiang T, Zhang XO, Weng Z, Xue W. Deletion and replacement of long genomic sequences using prime editing. Nat Biotechnol. 2022 02; 40(2):227-234.

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Paes Dias M, Tripathi V, van der Heijden I, Cong K, Manolika EM, Bhin J, Gogola E, Galanos P, Annunziato S, Lieftink C, Andújar-Sánchez M, Chakrabarty S, Smith GCM, van de Ven M, Beijersbergen RL, Bartkova J, Rottenberg S, Cantor S, Bartek J, Ray Chaudhuri A, Jonkers J. Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps. Mol Cell. 2021 11 18; 81(22):4692-4708.e9.

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Ghanta KS, Ishidate T, Mello CC. Microinjection for precision genome editing in Caenorhabditis elegans. STAR Protoc. 2021 09 17; 2(3):100748.

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Flotte TR. Base Editing to the Rescue. Hum Gene Ther. 2021 Jul; 32(13-14):647-648.

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