CRISPR-Associated Proteins

"CRISPR-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein components of the CRISPR-CAS SYSTEMS for anti-viral defense in ARCHAEA and BACTERIA. These are proteins that carry out a variety of functions during the creation and expansion of the CRISPR ARRAYS, the capture of new CRISPR SPACERS, biogenesis of SMALL INTERFERING RNA (CRISPR or crRNAs), and the targeting and silencing of invading viruses and plasmids. They include DNA HELICASES; RNA-BINDING PROTEINS; ENDONUCLEASES; and RNA and DNA POLYMERASES.

Descriptor ID	D064130
MeSH Number(s)	D12.776.212
Concept/Terms	CRISPR-Associated Proteins CRISPR-Associated Proteins CRISPR Associated Proteins Proteins, CRISPR-Associated CRISPR-Associated Protein Complex Proteins CRISPR-Associated Protein Complex Proteins CRISPR Associated Protein Complex Proteins CRISPR-Associated Complex for Antiviral Defense Proteins CRISPR Associated Complex for Antiviral Defense Proteins CASCADE Proteins, CRISPR-Associated CASCADE Proteins, CRISPR Associated CRISPR-Associated CASCADE Proteins Repeat-Associated Mysterious Proteins Repeat-Associated Mysterious Proteins Proteins, Repeat-Associated Mysterious Repeat Associated Mysterious Proteins

Below are MeSH descriptors whose meaning is more general than "CRISPR-Associated Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
CRISPR-Associated Proteins [D12.776.212]

Below are MeSH descriptors whose meaning is related to "CRISPR-Associated Proteins".

Below are MeSH descriptors whose meaning is more specific than "CRISPR-Associated Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CRISPR-Associated Proteins" by people in this website by year, and whether "CRISPR-Associated Proteins" was a major or minor topic of these publications.

Bar chart showing 18 publications over 9 distinct years, with a maximum of 7 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	4	3	7
2015	1	0	1
2016	2	0	2
2017	1	0	1
2019	1	0	1
2020	1	1	2
2021	1	0	1
2023	2	0	2
2024	1	0	1

Below are the most recent publications written about "CRISPR-Associated Proteins" by people in Profiles.

Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, Tsuchida CA, Tran RV, Hofman L, Shi H, Wasko KM, Zhou Z, Xia C, Al-Shimary MJ, Patel JR, Thomas VCJX, Pattali R, Kan MJ, Vardapetyan A, Yang A, Lahiri A, Maxwell MF, Murdock AG, Ramit GC, Henderson HR, Calvert RW, Bamert RS, Knott GJ, Lapinaite A, Pausch P, Cofsky JC, Sontheimer EJ, Wiedenheft B, Fineran PC, Brouns SJJ, Sashital DG, Thomas BC, Brown CT, Goltsman DSA, Barrangou R, Siksnys V, Banfield JF, Savage DF, Doudna JA. CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Nucleic Acids Res. 2024 Jan 05; 52(D1):D590-D596.

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Park JU, Petassi MT, Hsieh SC, Mehrotra E, Schuler G, Budhathoki J, Truong VH, Thyme SB, Ke A, Kellogg EH, Peters JE. Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition. Mol Cell. 2023 06 01; 83(11):1827-1838.e6.

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Rish AD, Fu TM. CRISPR-Cas has a new juggling act: interplay between nuclease and protease. Nat Struct Mol Biol. 2023 02; 30(2):126-128.

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Wu C, Tang D, Cheng J, Hu D, Yang Z, Ma X, He H, Yao S, Fu TM, Yu Y, Chen Q. Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res. 2021 03 18; 49(5):2973-2984.

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Barrangou R, Sontheimer EJ. Shutting down RNA-targeting CRISPR. Science. 2020 07 03; 369(6499):31-32.

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Davidson AR, Lu WT, Stanley SY, Wang J, Mejdani M, Trost CN, Hicks BT, Lee J, Sontheimer EJ. Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems. Annu Rev Biochem. 2020 Jun 20; 89:309-332.

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Iyer S, Suresh S, Guo D, Daman K, Chen JCJ, Liu P, Zieger M, Luk K, Roscoe BP, Mueller C, King OD, Emerson CP, Wolfe SA. Precise therapeutic gene correction by a simple nuclease-induced double-stranded break. Nature. 2019 04; 568(7753):561-565.

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Mir A, Edraki A, Lee J, Sontheimer EJ. Type II-C CRISPR-Cas9 Biology, Mechanism, and Application. ACS Chem Biol. 2018 Feb 16; 13(2):357-365.

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Thyme SB, Akhmetova L, Montague TG, Valen E, Schier AF. Internal guide RNA interactions interfere with Cas9-mediated cleavage. Nat Commun. 2016 Jun 10; 7:11750.

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Sontheimer EJ, Marraffini LA. RNA. CRISPR goes retro. Science. 2016 Feb 26; 351(6276):920-1.

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