Checkpoint Kinase 2

"Checkpoint Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.

Descriptor ID	D064447
MeSH Number(s)	D08.811.913.696.620.682.700.145
Concept/Terms	Checkpoint Kinase 2 Checkpoint Kinase 2 Kinase 2, Checkpoint Chk2 Protein Kinase Kinase, Chk2 Protein Protein Kinase, Chk2 Checkpoint-Like Protein CHK2 CHK2, Checkpoint-Like Protein Checkpoint Like Protein CHK2 Protein CHK2, Checkpoint-Like Serine Threonine Protein Kinase Chk2 LFS2 Protein Kinase Kinase, LFS2 Protein Protein Kinase, LFS2 CHEK2 Kinase Kinase, CHEK2 hCHK2 Kinase Kinase, hCHK2 Serine-Threonine-Protein Kinase CHK2 CHK2, Serine-Threonine-Protein Kinase Kinase CHK2, Serine-Threonine-Protein CDS1 Kinase Kinase, CDS1 PP1425 Protein Kinase Kinase, PP1425 Protein Protein Kinase, PP1425

Below are MeSH descriptors whose meaning is more general than "Checkpoint Kinase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]

Below are MeSH descriptors whose meaning is related to "Checkpoint Kinase 2".

Below are MeSH descriptors whose meaning is more specific than "Checkpoint Kinase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Checkpoint Kinase 2" by people in this website by year, and whether "Checkpoint Kinase 2" was a major or minor topic of these publications.

Bar chart showing 22 publications over 14 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2004	0	3	3
2005	0	2	2
2006	0	1	1
2007	0	2	2
2008	0	2	2
2009	0	1	1
2010	0	4	4
2012	0	1	1
2013	1	0	1
2016	0	1	1
2018	1	0	1
2020	1	0	1

Below are the most recent publications written about "Checkpoint Kinase 2" by people in Profiles.

Das A, Martinez Santos JL, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. In?Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells. Cancer Invest. 2020 Jul; 38(6):349-355.

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Gong J, Zheng Y, Wang Y, Sheng W, Li Y, Liu X, Si S, Shao R, Zhen Y. A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway. PLoS One. 2018; 13(2):e0191984.

View in: PubMed
Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N. Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3676-85.

View in: PubMed
Edenberg ER, Vashisht A, Benanti JA, Wohlschlegel J, Toczyski DP. Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Mol Cell Biol. 2014 Feb; 34(4):725-38.

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Yang HW, Kim TM, Song SS, Shrinath N, Park R, Kalamarides M, Park PJ, Black PM, Carroll RS, Johnson MD. Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma. Neoplasia. 2012 Jan; 14(1):20-8.

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Garabedian MV, Noguchi C, Ziegler MA, Das MM, Singh T, Harper LJ, Leman AR, Khair L, Moser BA, Nakamura TM, Noguchi E. The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe. Genetics. 2012 Feb; 190(2):487-500.

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Kaufman PD. Toxicity and lifespan extension: complex outcomes of histone overexpression in budding yeast. Cell Cycle. 2010 Dec 01; 9(23):4611-2.

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Limbo O, Porter-Goff ME, Rhind N, Russell P. Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol Cell Biol. 2011 Feb; 31(3):573-83.

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Khair L, Chang YT, Subramanian L, Russell P, Nakamura TM. Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance. Cell Cycle. 2010 Jun 01; 9(11):2237-48.

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Varmark H, Kwak S, Theurkauf WE. A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells. Cell Cycle. 2010 Jan 15; 9(2):312-20.

View in: PubMed

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