"Pyrin Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein interaction domain of the death domain superfamily. It is characterized by a 6-helix bundle similar to those that occur in DEATH DOMAIN RECEPTORS. Pyrin domains are present in a variety of proteins, especially those that function in INFLAMMASOMES; AUTOPHAGY; and APOPTOSIS. They form homodimers or heterodimers with death domain proteins to facilitate the assembly of signaling complexes.
| Descriptor ID |
D000071196
|
| MeSH Number(s) |
G02.111.570.820.709.275.750.500.395.875
|
| Concept/Terms |
Pyrin Domain- Pyrin Domain
- Pyrin Domains
- DAPIN Domain
- DAPIN Domains
- PAAD-DAPIN-PYRIN Domain
- PAAD DAPIN PYRIN Domain
- PAAD-DAPIN-PYRIN Domains
- PYD Domain
- PYD Domains
- PADD Domain
- PADD Domains
|
Below are MeSH descriptors whose meaning is more general than "Pyrin Domain".
Below are MeSH descriptors whose meaning is more specific than "Pyrin Domain".
This graph shows the total number of publications written about "Pyrin Domain" by people in this website by year, and whether "Pyrin Domain" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Pyrin Domain" by people in Profiles.
-
Rahman T, Nagar A, Duffy EB, Okuda K, Silverman N, Harton JA. NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features. Front Immunol. 2020; 11:1828.
-
Yang G, Lee HE, Moon SJ, Ko KM, Koh JH, Seok JK, Min JK, Heo TH, Kang HC, Cho YY, Lee HS, Fitzgerald KA, Lee JY. Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis. Arthritis Rheumatol. 2020 07; 72(7):1192-1202.
-
Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickh?fer S, Daiber E, M?nzenmayer L, Wahl S, Rieber N, K?mmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR. Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase. J Allergy Clin Immunol. 2017 Oct; 140(4):1054-1067.e10.