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Subretinal delivery of recombinant AAV serotype 8 vector in dogs results in gene transfer to neurons in the brain.
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 2007 Oct; 12(4):342-54.
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subject areas
Animals
Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins
Cell Line, Tumor
DNA Damage
DNA-Binding Proteins
Fibroblasts
Homeostasis
Humans
Mice
Mice, Knockout
Mutation
Osteosarcoma
Phosphoprotein Phosphatases
Phosphorylation
Proteasome Endopeptidase Complex
Protein Phosphatase 2C
Proto-Oncogene Proteins c-mdm2
RNA Interference
RNA, Small Interfering
Serine
Signal Transduction
Time Factors
Transcription, Genetic
Transfection
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
Ubiquitin
Ubiquitin Thiolesterase
Ubiquitin-Specific Peptidase 7