Toll-Like Receptor 9

"Toll-Like Receptor 9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A pattern recognition receptor that binds unmethylated CPG CLUSTERS. It mediates cellular responses to bacterial pathogens by distinguishing between self and bacterial DNA.

Descriptor ID	D051217
MeSH Number(s)	D12.776.260.750 D12.776.543.750.705.910.500.900
Concept/Terms	Toll-Like Receptor 9 Toll-Like Receptor 9 Toll Like Receptor 9 TLR9 Receptor Receptor, TLR9 TLR9 Protein CD289 Antigen Antigen, CD289

Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 9".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Toll-Like Receptor 9 [D12.776.260.750]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Pattern Recognition [D12.776.543.750.705.910]
Toll-Like Receptors [D12.776.543.750.705.910.500]
Toll-Like Receptor 9 [D12.776.543.750.705.910.500.900]

Below are MeSH descriptors whose meaning is related to "Toll-Like Receptor 9".

Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 9".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Toll-Like Receptor 9" by people in this website by year, and whether "Toll-Like Receptor 9" was a major or minor topic of these publications.

Bar chart showing 137 publications over 22 distinct years, with a maximum of 19 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	2	2
2003	0	4	4
2004	0	15	15
2005	0	9	9
2006	9	0	9
2007	14	5	19
2008	11	2	13
2009	7	1	8
2010	6	1	7
2011	4	2	6
2012	3	3	6
2013	8	3	11
2014	2	3	5
2015	3	2	5
2016	1	0	1
2017	2	3	5
2018	1	1	2
2019	1	3	4
2020	2	1	3
2021	1	0	1
2022	0	1	1

Below are the most recent publications written about "Toll-Like Receptor 9" by people in Profiles.

Kugler-Umana O, Zhang W, Kuang Y, Liang J, Castonguay CH, Tonkonogy SL, Marshak-Rothstein A, Devarajan P, Swain SL. IgD+ age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged. Aging Cell. 2022 Oct; 21(10):e13705.

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Ribas A, Medina T, Kirkwood JM, Zakharia Y, Gonzalez R, Davar D, Chmielowski B, Campbell KM, Bao R, Kelley H, Morris A, Mauro D, Wooldridge JE, Luke JJ, Weiner GJ, Krieg AM, Milhem MM. Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma. Cancer Discov. 2021 12 01; 11(12):2998-3007.

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Miller PG, Sperling AS, Gibson CJ, Viswanathan K, Castellano C, McConkey M, Ceremsak J, Taylor MS, Birndt S, Perner F, Arnason J, Agrawal M, Schram AM, Nikiforow S, Pihan G, Hasserjian RP, Aster JC, La Ros?e P, Morgan EA, Berliner N, Ebert BL. Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis. Blood. 2020 12 24; 136(26):3051-3055.

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Chen X, Yang X, de Anda J, Huang J, Li D, Xu H, Shields KS, D?unkov? M, Hansen J, Patel IJ, Yee EU, Golenbock DT, Grant MA, Wong GCL, Kelly CP. Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling. Gastroenterology. 2020 12; 159(6):2181-2192.e1.

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Lemke-Miltner CD, Blackwell SE, Yin C, Krug AE, Morris AJ, Krieg AM, Weiner GJ. Antibody Opsonization of a TLR9 Agonist-Containing Virus-like Particle Enhances In Situ Immunization. J Immunol. 2020 03 01; 204(5):1386-1394.

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Lai JJ, Cruz FM, Rock KL. Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury. Immunity. 2020 01 14; 52(1):123-135.e6.

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Khan NS, Lukason DP, Feliu M, Ward RA, Lord AK, Reedy JL, Ramirez-Ortiz ZG, Tam JM, Kasperkovitz PV, Negoro PE, Vyas TD, Xu S, Brinkmann MM, Acharaya M, Artavanis-Tsakonas K, Frickel EM, Becker CE, Dagher Z, Kim YM, Latz E, Ploegh HL, Mansour MK, Miranti CK, Levitz SM, Vyas JM. CD82 controls CpG-dependent TLR9 signaling. FASEB J. 2019 11; 33(11):12500-12514.

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Qiu CC, Atencio AE, Gallucci S. Inhibition of fatty acid metabolism by etomoxir or TOFA suppresses murine dendritic cell activation without affecting viability. Immunopharmacol Immunotoxicol. 2019 Jun; 41(3):361-369.

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Backlund CM, Parhamifar L, Minter L, Tew GN, Andresen TL. Protein Transduction Domain Mimics Facilitate Rapid Antigen Delivery into Monocytes. Mol Pharm. 2019 06 03; 16(6):2462-2469.

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Frelinger AL, Gerrits AJ, Neculaes VB, Gremmel T, Torres AS, Caiafa A, Carmichael SL, Michelson AD. Tunable activation of therapeutic platelet-rich plasma by pulse electric field: Differential effects on clot formation, growth factor release, and platelet morphology. PLoS One. 2018; 13(9):e0203557.

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