Transcription Factor AP-2

"Transcription Factor AP-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

Descriptor ID	D050656
MeSH Number(s)	D12.776.260.760 D12.776.930.907
Concept/Terms	Transcription Factor AP-2 Transcription Factor AP-2 AP-2, Transcription Factor Transcription Factor AP 2 Transcription Factor AP2 Enhancer-Binding Protein AP-2 AP-2, Enhancer-Binding Protein Enhancer Binding Protein AP 2 Activator Protein AP-2 AP-2, Activator Protein Activator Protein AP 2 AP-2 Enhancer Binding Protein AP 2 Enhancer Binding Protein Transcription Factor AP-2 epsilon Protein Transcription Factor AP-2 epsilon Protein Transcription Factor AP 2 epsilon Protein Transcription Factor AP-2epsilon AP-2epsilon, Transcription Factor Transcription Factor AP 2epsilon AP-2 epsilon Protein Transcription Factor AP-2 beta Protein Transcription Factor AP-2 beta Protein Transcription Factor AP 2 beta Protein TFAP2B Protein Transcription Factor AP-2beta AP-2beta, Transcription Factor Transcription Factor AP 2beta AP-2 beta Protein AP 2 beta Protein Transcription Factor AP-2 delta Protein Transcription Factor AP-2 delta Protein Transcription Factor AP 2 delta Protein Transcription Factor Ap-2delta Ap-2delta, Transcription Factor Transcription Factor Ap 2delta AP-2delta Protein AP 2delta Protein Transcription Factor AP-2 gamma Protein Transcription Factor AP-2 gamma Protein Transcription Factor AP 2 gamma Protein Transcription Factor AP-2gamma AP-2gamma, Transcription Factor Transcription Factor AP 2gamma AP-2 gamma Protein AP 2 gamma Protein Transcription Factor AP-2 alpha Protein Transcription Factor AP-2 alpha Protein Transcription Factor AP 2 alpha Protein AP-2 alpha Protein AP 2 alpha Protein TFAP2alpha Protein Transcription Factor AP-2alpha AP-2alpha, Transcription Factor Transcription Factor AP 2alpha

Below are MeSH descriptors whose meaning is more general than "Transcription Factor AP-2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Transcription Factor AP-2 [D12.776.260.760]
Transcription Factors [D12.776.930]
Transcription Factor AP-2 [D12.776.930.907]

Below are MeSH descriptors whose meaning is related to "Transcription Factor AP-2".

Below are MeSH descriptors whose meaning is more specific than "Transcription Factor AP-2".

publications

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Below are the most recent publications written about "Transcription Factor AP-2" by people in Profiles.

Afzal F, Pratap J, Ito K, Ito Y, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Javed A. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol. 2005 Jul; 204(1):63-72.

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Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr; 203(1):133-43.

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Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ. The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem. 2005 May 27; 280(21):20274-85.

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Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB. SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 2005 Mar 01; 94(4):720-30.

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Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, van Wijnen A, Lian JB, Stein GS, Stein JL, Montecino M. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol. 2004 Oct; 24(20):8847-61.

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Zaidi SK, Sullivan AJ, Medina R, Ito Y, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J. 2004 Feb 25; 23(4):790-9.

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Guti?rrez J, Sierra J, Medina R, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M. Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site. Biochemistry. 2000 Nov 07; 39(44):13565-74.

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Zeng C, van Wijnen AJ, Stein JL, Meyers S, Sun W, Shopland L, Lawrence JB, Penman S, Lian JB, Stein GS, Hiebert SW. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6746-51.

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