A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

Descriptor ID	D037761
MeSH Number(s)	D08.811.277.087.520.200.650 D08.811.913.400.725.115.961 D12.776.476.900
Concept/Terms	Sirtuins Sirtuins Sir2-like Proteins Sir2 like Proteins Silent Mating Type Information Regulator 2-like Proteins Silent Mating Type Information Regulator 2 like Proteins

Below are MeSH descriptors whose meaning is more general than "Sirtuins".

Below are MeSH descriptors whose meaning is related to "Sirtuins".

Below are MeSH descriptors whose meaning is more specific than "Sirtuins".