Receptors, Notch

"Receptors, Notch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.

Descriptor ID	D051880
MeSH Number(s)	D12.776.543.750.725 D12.776.930.770
Concept/Terms	Receptors, Notch Receptors, Notch Notch Proteins Notch Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, Notch".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Notch [D12.776.543.750.725]
Transcription Factors [D12.776.930]
Receptors, Notch [D12.776.930.770]

Below are MeSH descriptors whose meaning is related to "Receptors, Notch".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Notch".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Notch" by people in this website by year, and whether "Receptors, Notch" was a major or minor topic of these publications.

Bar chart showing 81 publications over 21 distinct years, with a maximum of 8 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	3	3
2000	0	1	1
2002	0	2	2
2003	0	4	4
2005	0	4	4
2006	3	2	5
2007	3	2	5
2008	3	2	5
2009	5	1	6
2010	6	2	8
2011	5	2	7
2012	4	0	4
2013	4	2	6
2014	3	1	4
2015	2	2	4
2016	0	2	2
2017	0	1	1
2018	4	1	5
2020	1	1	2
2021	0	2	2
2024	0	1	1

Below are the most recent publications written about "Receptors, Notch" by people in Profiles.

Watson EV, Lee JJ, Gulhan DC, Melloni GEM, Venev SV, Magesh RY, Frederick A, Chiba K, Wooten EC, Naxerova K, Dekker J, Park PJ, Elledge SJ. Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nat Genet. 2024 May; 56(5):900-912.

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Maicas M, Jimeno-Mart?n ?, Mill?n-Trejo A, Alkema MJ, Flames N. The transcription factor LAG-1/CSL plays a Notch-independent role in controlling terminal differentiation, fate maintenance, and plasticity of serotonergic chemosensory neurons. PLoS Biol. 2021 07; 19(7):e3001334.

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Peloggia J, M?nch D, Meneses-Giles P, Romero-Carvajal A, Lush ME, Lawson ND, McClain M, Pan YA, Piotrowski T. Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes. Dev Cell. 2021 05 03; 56(9):1296-1312.e7.

View in: PubMed
Majumder S, Crabtree JS, Golde TE, Minter LM, Osborne BA, Miele L. Targeting Notch in oncology: the path forward. Nat Rev Drug Discov. 2021 02; 20(2):125-144.

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Czerminski JT, Lawrence JB. Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation. Dev Cell. 2020 02 10; 52(3):294-308.e3.

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Kelliher MA, Roderick JE. NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies. Front Immunol. 2018; 9:1718.

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Kourtis N, Lazaris C, Hockemeyer K, Balandr?n JC, Jimenez AR, Mullenders J, Gong Y, Trimarchi T, Bhatt K, Hu H, Shrestha L, Ambesi-Impiombato A, Kelliher M, Paietta E, Chiosis G, Guzman ML, Ferrando AA, Tsirigos A, Aifantis I. Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nat Med. 2018 08; 24(8):1157-1166.

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Wongchana W, Kongkavitoon P, Tangtanatakul P, Sittplangkoon C, Butta P, Chawalitpong S, Pattarakankul T, Osborne BA, Palaga T. Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes. PLoS One. 2018; 13(6):e0198609.

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Hossain F, Majumder S, Ucar DA, Rodriguez PC, Golde TE, Minter LM, Osborne BA, Miele L. Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses. Front Immunol. 2018; 9:1288.

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Vijayaraghavan J, Osborne BA. Notch and T Cell Function - A Complex Tale. Adv Exp Med Biol. 2018; 1066:339-354.

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