Monomeric GTP-Binding Proteins

"Monomeric GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. This enzyme was formerly listed as EC 3.6.1.47

Descriptor ID	D020559
MeSH Number(s)	D08.811.277.040.330.300.400 D12.644.360.525 D12.776.157.325.515 D12.776.476.525
Concept/Terms	Monomeric GTP-Binding Proteins Monomeric GTP-Binding Proteins Monomeric GTP Binding Proteins Small GTPases GTPases, Small Monomeric G-Proteins Monomeric G Proteins Small G-Proteins G-Proteins, Small Small G Proteins G-Proteins, Monomeric G Proteins, Monomeric GTP-Binding Proteins, Monomeric GTP Binding Proteins, Monomeric ras-Related GTPases ras-Related GTPases GTPases, ras-Related ras Related GTPases ras-Related GTP-Binding Proteins GTP-Binding Proteins, ras-Related Proteins, ras-Related GTP-Binding ras Related GTP Binding Proteins ras-Related G-Proteins G-Proteins, ras-Related ras Related G Proteins

Below are MeSH descriptors whose meaning is more general than "Monomeric GTP-Binding Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Monomeric GTP-Binding Proteins [D12.644.360.525]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Monomeric GTP-Binding Proteins [D12.776.157.325.515]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Monomeric GTP-Binding Proteins [D12.776.476.525]

Below are MeSH descriptors whose meaning is related to "Monomeric GTP-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "Monomeric GTP-Binding Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Monomeric GTP-Binding Proteins" by people in this website by year, and whether "Monomeric GTP-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 26 publications over 12 distinct years, with a maximum of 4 publications in 2019 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2011	0	1	1
2012	0	1	1
2014	1	1	2
2015	1	1	2
2017	1	1	2
2018	3	0	3
2019	3	1	4
2020	1	0	1
2021	4	0	4
2022	3	0	3
2023	2	0	2

Below are the most recent publications written about "Monomeric GTP-Binding Proteins" by people in Profiles.

Tettoni SD, Egri SB, Doxsey DD, Veinotte K, Ouch C, Chang JY, Song K, Xu C, Shen K. Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure. 2023 09 07; 31(9):1065-1076.e5.

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Doxsey DD, Tettoni SD, Egri SB, Shen K. Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells. J Biol Chem. 2023 07; 299(7):104880.

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Doxsey DD, Shen K. Purification and biochemical characterization of the Rag GTPase heterodimer. Methods Enzymol. 2022; 675:131-158.

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Egri SB, Ouch C, Chou HT, Yu Z, Song K, Xu C, Shen K. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol Cell. 2022 05 19; 82(10):1836-1849.e5.

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Doxsey DD, Veinotte K, Shen K. A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of S. cerevisiae. Small GTPases. 2022 01; 13(1):327-334.

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Perica T, Mathy CJP, Xu J, Jang G?, Zhang Y, Kaake R, Ollikainen N, Braberg H, Swaney DL, Lambright DG, Kelly MJS, Krogan NJ, Kortemme T. Systems-level effects of allosteric perturbations to a model molecular switch. Nature. 2021 11; 599(7883):152-157.

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Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleiner?schkamp F, Oh J, Godefroid N, Eltan M, G?ran T, Burtey S, Parotte MC, K?nig J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altm?ller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF. mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy. J Am Soc Nephrol. 2021 11; 32(11):2885-2899.

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Fagan RR, Kearney PJ, Luethi D, Bolden NC, Sitte HH, Emery P, Melikian HE. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Mol Psychiatry. 2021 12; 26(12):7793-7802.

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Egri SB, Shen K. An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids. J Biol Chem. 2021 07; 297(1):100861.

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Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O'Connor LC, Sitte HH, Melikian HE. Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. J Biol Chem. 2020 04 17; 295(16):5229-5244.

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