 Protein Phosphatase 2
"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
| Descriptor ID |
D054648
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| MeSH Number(s) |
D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
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| Concept/Terms |
Protein Phosphatase 2, Catalytic Subunit, alpha Isoform- Protein Phosphatase 2, Catalytic Subunit, alpha Isoform
- Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform
- Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform
- PPP2CA Phosphatase
- Phosphatase, PPP2CA
Protein Phosphatase 2, Catalytic Subunit, beta Isoform- Protein Phosphatase 2, Catalytic Subunit, beta Isoform
- Protein Phosphatase 2A, Catalytic Subunit, beta Isoform
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform
- PPP2CB Phosphatase
- Phosphatase, PPP2CB
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Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".
This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.
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Rahman A, Takahashi M, Shibasaki K, Wu S, Inaba T, Tsurumi S, Baskin TI. Gravitropism of Arabidopsis thaliana roots requires the polarization of PIN2 toward the root tip in meristematic cortical cells. Plant Cell. 2010 Jun; 22(6):1762-76.
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Tikh EI, Fenton RA, Chen JF, Schwarzschild MA, Dobson JG. Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart. J Cell Physiol. 2008 Jul; 216(1):83-90.
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Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006 Jan 1; 66(1):331-42.
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Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell. 2005 Dec 9; 20(5):801-9.
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Fenton RA, Dickson EW, Dobson JG. Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart. Life Sci. 2005 Nov 12; 77(26):3375-88.
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Lizotte DL, McManus DD, Cohen HR, DeLong A. Functional expression of human and Arabidopsis protein phosphatase 2A in Saccharomyces cerevisiae and isolation of dominant-defective mutants. Gene. 1999 Jun 24; 234(1):35-44.
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Essler M, Hermann K, Amano M, Kaibuchi K, Heesemann J, Weber PC, Aepfelbacher M. Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase. J Immunol. 1998 Nov 15; 161(10):5640-6.
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