CARD Signaling Adaptor Proteins

"CARD Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intracellular signaling adaptor proteins that contain CASPASE ACTIVATION AND RECRUITMENT DOMAINS (CARD). They play a role in APOPTOSIS-related signal transduction by associating with other CARD domain-containing members and activating INITIATOR CASPASES that contain CARD domains within their N-terminal pro-domain region.

Descriptor ID	D053468
MeSH Number(s)	D12.644.360.024.131 D12.644.360.075.358 D12.776.157.057.006 D12.776.476.024.139 D12.776.476.075.358
Concept/Terms	CARD Signaling Adaptor Proteins CARD Signaling Adaptor Proteins Caspase Activation and Recruitment Domain Signaling Proteins

Below are MeSH descriptors whose meaning is more general than "CARD Signaling Adaptor Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
CARD Signaling Adaptor Proteins [D12.644.360.024.131]
Apoptosis Regulatory Proteins [D12.644.360.075]
CARD Signaling Adaptor Proteins [D12.644.360.075.358]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
CARD Signaling Adaptor Proteins [D12.776.157.057.006]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
CARD Signaling Adaptor Proteins [D12.776.476.024.139]
Apoptosis Regulatory Proteins [D12.776.476.075]
CARD Signaling Adaptor Proteins [D12.776.476.075.358]

Below are MeSH descriptors whose meaning is related to "CARD Signaling Adaptor Proteins".

Below are MeSH descriptors whose meaning is more specific than "CARD Signaling Adaptor Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CARD Signaling Adaptor Proteins" by people in this website by year, and whether "CARD Signaling Adaptor Proteins" was a major or minor topic of these publications.

Bar chart showing 30 publications over 13 distinct years, with a maximum of 5 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2009	0	1	1
2010	0	4	4
2012	0	2	2
2013	0	5	5
2014	0	4	4
2015	0	1	1
2016	2	0	2
2017	1	1	2
2018	2	1	3
2019	1	0	1
2020	2	1	3
2021	0	1	1

Below are the most recent publications written about "CARD Signaling Adaptor Proteins" by people in Profiles.

Jiang S, Maphis NM, Binder J, Chisholm D, Weston L, Duran W, Peterson C, Zimmerman A, Mandell MA, Jett SD, Bigio E, Geula C, Mellios N, Weick JP, Rosenberg GA, Latz E, Heneka MT, Bhaskar K. Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep. 2021 09 21; 36(12):109720.

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Ravimohan S, Maenetje P, Auld SC, Ncube I, Mlotshwa M, Chase W, Tiemessen CT, Vangu MD, Wallis RS, Churchyard G, Weissman D, Kornfeld H, Bisson GP. A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis. Clin Infect Dis. 2020 08 14; 71(4):924-932.

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Campuzano A, Zhang H, Ostroff GR, Dos Santos Dias L, W?thrich M, Klein BS, Yu JJ, Lara HH, Lopez-Ribot JL, Hung CY. CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection. J Immunol. 2020 06 15; 204(12):3296-3306.

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Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT. ?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia. Cell Rep. 2020 03 17; 30(11):3743-3754.e6.

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Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt RE, Coonrod SA, Thompson PR, Lerch MM, Bossaller L. Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1? Maturation and ASC Speck Formation in Macrophages. J Immunol. 2019 08 15; 203(4):795-800.

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Rodr?guez-Alc?zar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenm?ller W, Latz E, Franklin BS. Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1? Inflammation in Human Macrophages. J Immunol. 2019 01 15; 202(2):550-558.

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Ahmad F, Mishra N, Ahrenstorf G, Franklin BS, Latz E, Schmidt RE, Bossaller L. Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients. AIDS. 2018 01 28; 32(3):299-307.

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Franklin BS, Latz E, Schmidt FI. The intra- and extracellular functions of ASC specks. Immunol Rev. 2018 01; 281(1):74-87.

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Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease. Nature. 2017 12 20; 552(7685):355-361.

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Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald KA. The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression. J Immunol. 2017 11 01; 199(9):3249-3260.

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