Pre-B-Cell Leukemia Transcription Factor 1
"Pre-B-Cell Leukemia Transcription Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.
| Descriptor ID |
D000075062
|
| MeSH Number(s) |
D12.776.260.400.836 D12.776.624.664.700.163 D12.776.930.712
|
| Concept/Terms |
Pre-B-Cell Leukemia Transcription Factor 1- Pre-B-Cell Leukemia Transcription Factor 1
- Pre B Cell Leukemia Transcription Factor 1
- PBX1 Homeobox Protein
- Homeobox Protein, PBX1
- Pre-B-Cell Leukemia Homeobox 1 Protein
- Pre B Cell Leukemia Homeobox 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Pre-B-Cell Leukemia Transcription Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Pre-B-Cell Leukemia Transcription Factor 1".
This graph shows the total number of publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in this website by year, and whether "Pre-B-Cell Leukemia Transcription Factor 1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in Profiles.
-
Cho OH, Mallappa C, Hern?ndez-Hern?ndez JM, Rivera-P?rez JA, Imbalzano AN. Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development. Dev Dyn. 2015 Jan; 244(1):43-55.
-
Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Cells Tissues Organs. 2011; 194(2-4):146-50.
-
Gordon JA, Hassan MQ, Saini S, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Mol Cell Biol. 2010 Jul; 30(14):3531-41.
-
de la Serna IL, Ohkawa Y, Berkes CA, Bergstrom DA, Dacwag CS, Tapscott SJ, Imbalzano AN. MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex. Mol Cell Biol. 2005 May; 25(10):3997-4009.
-
Sagerstr?m CG. PbX marks the spot. Dev Cell. 2004 Jun; 6(6):737-8.
-
Choe SK, Vlachakis N, Sagerstr?m CG. Meis family proteins are required for hindbrain development in the zebrafish. Development. 2002 Feb; 129(3):585-95.
-
Vlachakis N, Ellstrom DR, Sagerstr?m CG. A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b. Dev Dyn. 2000 Jan; 217(1):109-19.