Retinoblastoma Protein

"Retinoblastoma Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.

Descriptor ID	D016160
MeSH Number(s)	D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770
Concept/Terms	Retinoblastoma Protein Retinoblastoma Protein Rb1 Gene Product Rb Gene Product Rb Protein p105-Rb Protein p105-Rb Protein p105 Rb Protein Retinoblastoma Nuclear Phosphoprotein p105-Rb Retinoblastoma Nuclear Phosphoprotein p105 Rb

Below are MeSH descriptors whose meaning is more general than "Retinoblastoma Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Retinoblastoma Protein [D12.776.260.704]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Retinoblastoma Protein [D12.776.624.776.745]
Nuclear Proteins [D12.776.660]
Retinoblastoma Protein [D12.776.660.807]
Phosphoproteins [D12.776.744]
Retinoblastoma Protein [D12.776.744.770]

Below are MeSH descriptors whose meaning is related to "Retinoblastoma Protein".

Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Retinoblastoma Protein" by people in this website by year, and whether "Retinoblastoma Protein" was a major or minor topic of these publications.

Bar chart showing 36 publications over 18 distinct years, with a maximum of 4 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	1	2
1997	0	1	1
2000	1	0	1
2001	0	2	2
2002	2	0	2
2003	1	1	2
2004	1	2	3
2005	0	3	3
2006	1	1	2
2007	1	1	2
2008	1	1	2
2009	1	0	1
2010	1	1	2
2011	0	2	2
2012	2	2	4
2014	0	1	1
2018	0	2	2
2020	0	2	2

Below are the most recent publications written about "Retinoblastoma Protein" by people in Profiles.

Das A, Alshareef M, Martinez Santos JL, Porto GBF, McDonald DG, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. Evaluating anti-tumor activity of palbociclib plus radiation in anaplastic and radiation-induced meningiomas: pre-clinical investigations. Clin Transl Oncol. 2020 Nov; 22(11):2017-2025.

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Ruscetti M, Morris JP, Mezzadra R, Russell J, Leibold J, Romesser PB, Simon J, Kulick A, Ho YJ, Fennell M, Li J, Norgard RJ, Wilkinson JE, Alonso-Curbelo D, Sridharan R, Heller DA, de Stanchina E, Stanger BZ, Sherr CJ, Lowe SW. Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Cell. 2020 04 16; 181(2):424-441.e21.

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Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018 12 21; 362(6421):1416-1422.

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Sun X, Kaufman PD. Ki-67: more than a proliferation marker. Chromosoma. 2018 06; 127(2):175-186.

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Zhang W, Chen H, Chen Y, Liu J, Wang X, Yu X, Chen JJ, Zhao W. Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1. Oncotarget. 2015 Mar 10; 6(7):5253-62.

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Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD. KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. Oncogene. 2015 Mar 12; 34(11):1432-41.

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Kumar P, Mukherjee M, Johnson JP, Patel M, Huey B, Albertson DG, Simin K. Cooperativity of Rb, Brca1, and p53 in malignant breast cancer evolution. PLoS Genet. 2012; 8(11):e1003027.

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Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, Strikoudis A, Genesca L, Trimarchi T, Kelliher MA, Clark M, Soulier J, Chen-Kiang S, Aifantis I. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell. 2012 Oct 16; 22(4):452-65.

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Chen BJ, Mariño-Enríquez A, Fletcher CD, Hornick JL. Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications. Am J Surg Pathol. 2012 Aug; 36(8):1119-28.

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Kleinerman RA, Yu CL, Little MP, Li Y, Abramson D, Seddon J, Tucker MA. Variation of second cancer risk by family history of retinoblastoma among long-term survivors. J Clin Oncol. 2012 Mar 20; 30(9):950-7.

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