Activating Transcription Factor 6

"Activating Transcription Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.

Descriptor ID	D051702
MeSH Number(s)	D12.644.360.011 D12.776.260.108.061.968 D12.776.476.011 D12.776.930.127.061.968
Concept/Terms	Activating Transcription Factor 6 Activating Transcription Factor 6 ATF6 Transcription Factor Transcription Factor, ATF6

Below are MeSH descriptors whose meaning is more general than "Activating Transcription Factor 6".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Activating Transcription Factor 6 [D12.644.360.011]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Activating Transcription Factors [D12.776.260.108.061]
Activating Transcription Factor 6 [D12.776.260.108.061.968]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Activating Transcription Factor 6 [D12.776.476.011]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
Activating Transcription Factors [D12.776.930.127.061]
Activating Transcription Factor 6 [D12.776.930.127.061.968]

Below are MeSH descriptors whose meaning is related to "Activating Transcription Factor 6".

Below are MeSH descriptors whose meaning is more specific than "Activating Transcription Factor 6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Activating Transcription Factor 6" by people in this website by year, and whether "Activating Transcription Factor 6" was a major or minor topic of these publications.

Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 2008 and 2010 and 2017

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2008	1	1
2010	1	1
2017	1	1

Below are the most recent publications written about "Activating Transcription Factor 6" by people in Profiles.

Charbord J, Ren L, Sharma RB, Johansson A, ?gren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF, Wang P, Alonso LC, Andersson O. In vivo screen identifies a SIK inhibitor that induces ? cell proliferation through a transient UPR. Nat Metab. 2021 05; 3(5):682-700.

View in: PubMed
Sharma RB, Darko C, Alonso LC. Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells. J Biol Chem. 2020 10 09; 295(41):14164-14177.

View in: PubMed
Sharma RB, Snyder JT, Alonso LC. Atf6a impacts cell number by influencing survival, death and proliferation. Mol Metab. 2019 09; 27S:S69-S80.

View in: PubMed
Alm PS, de Castro Barbosa T, Barr?s R, Krook A, Zierath JR. Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle. Mol Metab. 2017 07; 6(7):621-630.

View in: PubMed
Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE. The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget. 2016 Jan 12; 7(2):2080-92.

View in: PubMed
Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC. Insulin demand regulates ? cell number via the unfolded protein response. J Clin Invest. 2015 Oct 01; 125(10):3831-46.

View in: PubMed
Yang C, Diiorio P, Jurczyk A, O'Sullivan-Murphy B, Urano F, Bortell R. Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. Diabetologia. 2013 Dec; 56(12):2638-46.

View in: PubMed
Oslowski CM, Urano F. Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol. 2011; 490:71-92.

View in: PubMed
Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, Ron D, Urano F. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One. 2010 Mar 08; 5(3):e9575.

View in: PubMed
Fonseca SG, Ishigaki S, Oslowski CM, Lu S, Lipson KL, Ghosh R, Hayashi E, Ishihara H, Oka Y, Permutt MA, Urano F. Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest. 2010 Mar; 120(3):744-55.

View in: PubMed

People

Explore

Similar Concepts

Top Journals