 Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
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| MeSH Number(s) |
G02.111.830 G07.690.830
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| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
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Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1981 | 0 | 1 | 1 | | 1985 | 0 | 3 | 3 | | 1986 | 0 | 2 | 2 | | 1987 | 0 | 1 | 1 | | 1988 | 0 | 3 | 3 | | 1989 | 0 | 2 | 2 | | 1990 | 0 | 3 | 3 | | 1991 | 0 | 5 | 5 | | 1992 | 0 | 4 | 4 | | 1993 | 0 | 4 | 4 | | 1994 | 0 | 9 | 9 | | 1995 | 0 | 7 | 7 | | 1996 | 0 | 7 | 7 | | 1998 | 0 | 4 | 4 | | 1999 | 0 | 4 | 4 | | 2000 | 0 | 6 | 6 | | 2001 | 0 | 4 | 4 | | 2002 | 0 | 15 | 15 | | 2003 | 0 | 9 | 9 | | 2004 | 1 | 8 | 9 | | 2005 | 0 | 7 | 7 | | 2006 | 0 | 11 | 11 | | 2007 | 0 | 11 | 11 | | 2008 | 0 | 9 | 9 | | 2009 | 0 | 12 | 12 | | 2010 | 1 | 9 | 10 | | 2011 | 0 | 12 | 12 | | 2012 | 0 | 10 | 10 | | 2013 | 0 | 8 | 8 | | 2014 | 1 | 8 | 9 | | 2015 | 0 | 9 | 9 | | 2016 | 0 | 2 | 2 | | 2017 | 0 | 4 | 4 | | 2018 | 0 | 3 | 3 | | 2021 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Thada S, Horvath GL, Müller MM, Dittrich N, Conrad ML, Sur S, Hussain A, Pelka K, Gaddam SL, Latz E, Slevogt H, Schumann RR, Burkert S. Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis. Int J Mol Sci. 2021 Feb 04; 22(4).
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Rinis N, Golden JE, Marceau CD, Carette JE, Van Zandt MC, Gilmore R, Contessa JN. Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors. Cell Chem Biol. 2018 10 18; 25(10):1231-1241.e4.
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Atukorale PU, Guven ZP, Bekdemir A, Carney RP, Van Lehn RC, Yun DS, Jacob Silva PH, Demurtas D, Yang YS, Alexander-Katz A, Stellacci F, Irvine DJ. Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes. Bioconjug Chem. 2018 04 18; 29(4):1131-1140.
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Munro JB, Lee KK. Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein. Curr HIV Res. 2018; 16(1):5-12.
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Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Mol Cell. 2017 Nov 02; 68(3):552-565.e8.
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Schalbetter SA, Goloborodko A, Fudenberg G, Belton JM, Miles C, Yu M, Dekker J, Mirny L, Baxter J. SMC complexes differentially compact mitotic chromosomes according to genomic context. Nat Cell Biol. 2017 Sep; 19(9):1071-1080.
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Zhang Y, Zhao C, Tian G, Lu C, Li Y, He L, Xiao H, Zheng J. Simultaneous characterization of chemical structures and bioactivities of citrus-derived components using SERS barcodes. Food Chem. 2018 Feb 01; 240:743-750.
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Khurana L, Mackie K, Piomelli D, Kendall DA. Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities. Neuropharmacology. 2017 Sep 15; 124:3-12.
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Backlund CM, Takeuchi T, Futaki S, Tew GN. Relating structure and internalization for ROMP-based protein mimics. Biochim Biophys Acta. 2016 Jul; 1858(7 Pt A):1443-50.
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Previs MJ, Mun JY, Michalek AJ, Previs SB, Gulick J, Robbins J, Warshaw DM, Craig R. Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3239-44.
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