Orphan Nuclear Receptors

"Orphan Nuclear Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.

Descriptor ID	D057093
MeSH Number(s)	D12.776.260.643 D12.776.826.209 D12.776.930.645
Concept/Terms	Orphan Nuclear Receptors Orphan Nuclear Receptors Nuclear Receptors, Orphan Receptors, Orphan Nuclear

Below are MeSH descriptors whose meaning is more general than "Orphan Nuclear Receptors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Orphan Nuclear Receptors [D12.776.260.643]
Receptors, Cytoplasmic and Nuclear [D12.776.826]
Orphan Nuclear Receptors [D12.776.826.209]
Transcription Factors [D12.776.930]
Orphan Nuclear Receptors [D12.776.930.645]

Below are MeSH descriptors whose meaning is related to "Orphan Nuclear Receptors".

Below are MeSH descriptors whose meaning is more specific than "Orphan Nuclear Receptors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Orphan Nuclear Receptors" by people in this website by year, and whether "Orphan Nuclear Receptors" was a major or minor topic of these publications.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2011	1	1	2
2015	1	0	1
2023	1	0	1

Below are the most recent publications written about "Orphan Nuclear Receptors" by people in Profiles.

Goswamy D, Gonzalez X, Labed SA, Irazoqui JE. C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB. Front Immunol. 2023; 14:1094145.

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Tamehiro N, Park MH, Hawxhurst V, Nagpal K, Adams ME, Zannis VI, Golenbock DT, Fitzgerald ML. LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux. Biochemistry. 2015 Nov 24; 54(46):6931-41.

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Trasino SE, Dawson HD, Urban JF, Wang TT, Solano-Aguilar G. Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high-fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages. J Nutr Biochem. 2013 Nov; 24(11):1931-9.

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Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson J?, Holtzman DM, Heneka MT. Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial A? phagocytosis. J Neurosci. 2011 May 11; 31(19):7049-59.

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Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8.

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Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol. 2008 Apr; 28(7):2187-200.

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Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A. Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors. Hum Mol Genet. 2004 Aug 01; 13(15):1563-75.

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