Promyelocytic Leukemia Protein

"Promyelocytic Leukemia Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.

Descriptor ID	D000071156
MeSH Number(s)	D12.776.624.776.654 D12.776.660.745 D12.776.930.713 D12.776.934.500
Concept/Terms	Promyelocytic Leukemia Protein Promyelocytic Leukemia Protein RNF71 Protein TRIM19 Protein

Below are MeSH descriptors whose meaning is more general than "Promyelocytic Leukemia Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Promyelocytic Leukemia Protein [D12.776.624.776.654]
Nuclear Proteins [D12.776.660]
Promyelocytic Leukemia Protein [D12.776.660.745]
Transcription Factors [D12.776.930]
Promyelocytic Leukemia Protein [D12.776.930.713]
Tripartite Motif Proteins [D12.776.934]
Promyelocytic Leukemia Protein [D12.776.934.500]

Below are MeSH descriptors whose meaning is related to "Promyelocytic Leukemia Protein".

Below are MeSH descriptors whose meaning is more specific than "Promyelocytic Leukemia Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Promyelocytic Leukemia Protein" by people in this website by year, and whether "Promyelocytic Leukemia Protein" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2003	0	1	1
2004	0	1	1
2010	0	1	1
2012	0	1	1
2018	2	0	2
2020	1	0	1

Below are the most recent publications written about "Promyelocytic Leukemia Protein" by people in Profiles.

Shytaj IL, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese CK, Trifunovic A, Galy B, Eibl C, Silvestri G, Bicciato S, Savarino A, Lusic M. Alterations of redox and iron metabolism accompany the development of HIV latency. EMBO J. 2020 05 04; 39(9):e102209.

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Kordon MM, Szczurek A, Berniak K, Szelest O, Solarczyk K, Tworzydlo M, Wachsmann-Hogiu S, Vaahtokari A, Cremer C, Pederson T, Dobrucki JW. PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA replication-based single-strand breaks. FASEB J. 2019 02; 33(2):2301-2313.

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Merkl PE, Orzalli MH, Knipe DM. Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication. J Virol. 2018 05 15; 92(10).

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Erickson KD, Bouchet-Marquis C, Heiser K, Szomolanyi-Tsuda E, Mishra R, Lamothe B, Hoenger A, Garcea RL. Virion assembly factories in the nucleus of polyomavirus-infected cells. PLoS Pathog. 2012; 8(4):e1002630.

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Xiaofei E, Stadler BM, Debatis M, Wang S, Lu S, Kowalik TF. RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions. J Virol. 2012 May; 86(10):5660-73.

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Sinha S, Malonia SK, Mittal SP, Singh K, Kadreppa S, Kamat R, Mukhopadhyaya R, Pal JK, Chattopadhyay S. Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. EMBO J. 2010 Feb 17; 29(4):830-42.

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Smith KP, Byron M, O'Connell BC, Tam R, Schorl C, Guney I, Hall LL, Agrawal P, Sedivy JM, Lawrence JB. c-Myc localization within the nucleus: evidence for association with the PML nuclear body. J Cell Biochem. 2004 Dec 15; 93(6):1282-96.

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Favre M, Butticaz C, Stevenson B, Jongeneel CV, Telenti A. High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML. J Acquir Immune Defic Syndr. 2003 Oct 01; 34(2):127-33.

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Hemavathy K, Guru SC, Harris J, Chen JD, Ip YT. Human Slug is a repressor that localizes to sites of active transcription. Mol Cell Biol. 2000 Jul; 20(14):5087-95.

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Boulware SL, Weber PC. Cross-reactivity of the anti-PML antibody PG-M3 with the herpes simplex virus type 1 immediate early protein ICP4. J Gen Virol. 2000 Jul; 81(Pt 7):1773-7.

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