Cyclin-Dependent Kinase Inhibitor Proteins

"Cyclin-Dependent Kinase Inhibitor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION.

Descriptor ID	D050756
MeSH Number(s)	D12.644.360.225 D12.776.167.187 D12.776.476.225 D12.776.624.776.355
Concept/Terms	Cyclin-Dependent Kinase Inhibitor Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclin Dependent Kinase Inhibitor Proteins CKI Proteins CDKI Proteins Cyclin-Kinase Inhibitor Proteins Cyclin Kinase Inhibitor Proteins Inhibitor Proteins, Cyclin-Kinase CIP-KIP Cyclin-Dependent Kinase Inhibitors CIP-KIP Cyclin-Dependent Kinase Inhibitors CIP KIP Cyclin Dependent Kinase Inhibitors CIP-KIP CKI Proteins CIP KIP CKI Proteins CKI Proteins, CIP-KIP CIP-KIP CDKI Proteins CDKI Proteins, CIP-KIP CIP KIP CDKI Proteins INK4 Cyclin-Dependent Kinase Inhibitors INK4 Cyclin-Dependent Kinase Inhibitors INK4 Cyclin Dependent Kinase Inhibitors INK4 CDKI Proteins CDKI Proteins, INK4 INK4 CKI Proteins CKI Proteins, INK4 Inhibitors of Cyclin-Dependent Kinase 4 Proteins Inhibitors of Cyclin Dependent Kinase 4 Proteins

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.167.187]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinase Inhibitor Proteins".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor Proteins".

Cyclin-Dependent Kinase Inhibitor Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p18
Cyclin-Dependent Kinase Inhibitor p19
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinase Inhibitor p57

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor Proteins" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor Proteins" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 3 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1998	0	2	2
2001	0	1	1
2007	1	1	2
2008	0	1	1
2009	1	0	1
2011	1	0	1
2012	0	1	1
2014	2	1	3

Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor Proteins" by people in Profiles.

Pope PA, Bhaduri S, Pryciak PM. Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1. Curr Biol. 2014 Jun 16; 24(12):1390-1396.

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Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD. KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. Oncogene. 2015 Mar 12; 34(11):1432-41.

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Serra RW, Fang M, Park SM, Hutchinson L, Green MR. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12; 3:e02313.

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Wakai T, Vanderheyden V, Yoon SY, Cheon B, Zhang N, Parys JB, Fissore RA. Regulation of inositol 1,4,5-trisphosphate receptor function during mouse oocyte maturation. J Cell Physiol. 2012 Feb; 227(2):705-17.

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Kalchhauser I, Farley BM, Pauli S, Ryder SP, Ciosk R. FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans. EMBO J. 2011 Aug 05; 30(18):3823-9.

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Ambros V. pRB/CKI pathways at the interface of cell cycle and development. Cell Cycle. 2009 Nov 01; 8(21):3433-4.

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Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem. 2008 Sep 26; 283(39):26484-9.

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Strickfaden SC, Winters MJ, Ben-Ari G, Lamson RE, Tyers M, Pryciak PM. A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway. Cell. 2007 Feb 09; 128(3):519-31.

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Yu Y, Jiang X, Schoch BS, Carroll RS, Black PM, Johnson MD. Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. Cancer Res. 2007 Jan 01; 67(1):130-8.

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Ambros V. The temporal control of cell cycle and cell fate in Caenorhabditis elegans. Novartis Found Symp. 2001; 237:203-14; discussion 214-20.

View in: PubMed

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