WNK Lysine-Deficient Protein Kinase 1
"WNK Lysine-Deficient Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.
| Descriptor ID |
D000076204
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| MeSH Number(s) |
D08.811.913.696.620.682.700.982 D12.644.360.975 D12.776.476.944 D23.050.301.500.600.962 D23.050.705.552.600.925
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "WNK Lysine-Deficient Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "WNK Lysine-Deficient Protein Kinase 1".
This graph shows the total number of publications written about "WNK Lysine-Deficient Protein Kinase 1" by people in this website by year, and whether "WNK Lysine-Deficient Protein Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "WNK Lysine-Deficient Protein Kinase 1" by people in Profiles.
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Ye T, Mishra AK, Banday S, Li R, Hu K, Coleman MM, Shan Y, Chowdhury SR, Zhou L, Pak ML, Simone TM, Malonia SK, Zhu LJ, Kelliher MA, Green MR. Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma. Cell Rep. 2024 May 28; 43(5):114211.
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Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 03; 280(22):21622-8.