I-kappa B Kinase

"I-kappa B Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

Descriptor ID	D051550
MeSH Number(s)	D08.811.913.696.620.682.700.494 D12.644.360.361 D12.776.476.378
Concept/Terms	I-kappa B Kinase I-kappa B Kinase B Kinase, I-kappa Kinase, I-kappa B NK-kappa B-Activating Kinase NAK NK kappa B Activating Kinase NAK IkappaB Kinase Kinase, IkappaB I kappa B Kinase IkappaB Kinase gamma IkappaB Kinase gamma IKK gamma NF-kappaB Essential Modifier Essential Modifier, NF-kappaB NF kappaB Essential Modifier IkappaB Kinase epsilon IkappaB Kinase epsilon Kinase epsilon, IkappaB IKK epsilon IKKepsilon IkappaB Kinase alpha IkappaB Kinase alpha Kinase alpha, IkappaB IKK 1 Kinase IKK alpha Conserved Helix-Loop-Helix Ubiquitous Kinase Conserved Helix Loop Helix Ubiquitous Kinase CHUK Kinase I Kappa B alpha-Associated Protein Kinase I Kappa B alpha Associated Protein Kinase IkappaBalpha Kinase IkappaB Kinase beta IkappaB Kinase beta Kinase beta, IkappaB IKK beta IKBKB IKK 2 Kinase

Below are MeSH descriptors whose meaning is more general than "I-kappa B Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
I-kappa B Kinase [D08.811.913.696.620.682.700.494]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
I-kappa B Kinase [D12.644.360.361]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
I-kappa B Kinase [D12.776.476.378]

Below are MeSH descriptors whose meaning is related to "I-kappa B Kinase".

Below are MeSH descriptors whose meaning is more specific than "I-kappa B Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "I-kappa B Kinase" by people in this website by year, and whether "I-kappa B Kinase" was a major or minor topic of these publications.

Bar chart showing 38 publications over 15 distinct years, with a maximum of 5 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	2	2
2003	0	5	5
2004	0	4	4
2005	1	2	3
2006	2	1	3
2007	1	2	3
2008	3	0	3
2009	3	1	4
2011	0	2	2
2013	0	1	1
2014	1	0	1
2015	0	2	2
2017	1	0	1
2018	2	1	3
2019	0	1	1

Below are the most recent publications written about "I-kappa B Kinase" by people in Profiles.

Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-?B Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312.

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Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 11 30; 362(6418):1064-1069.

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Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL. The Kinase IKK? Regulates a STING- and NF-?B-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2018 08 21; 49(2):225-234.e4.

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Caracciolo V, Young J, Gonzales D, Ni Y, Flowers SJ, Summer R, Waldman SA, Kim JK, Jung DY, Noh HL, Kim T, Blackshear PJ, O'Connell D, Bauer RC, Kallen CB. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E676-E693.

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Rajurkar M, Dang K, Fernandez-Barrena MG, Liu X, Fernandez-Zapico ME, Lewis BC, Mao J. IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis. Cancer Res. 2017 01 15; 77(2):320-329.

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Johnston AM, Niemela J, Rosenzweig SD, Fried AJ, Delmonte OM, Fleisher TA, Kuehn H. A Novel Mutation in IKBKG/NEMO Leads to Ectodermal Dysplasia with Severe Immunodeficiency (EDA-ID). J Clin Immunol. 2016 08; 36(6):541-3.

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Yang Y, Kelly P, Shaffer AL, Schmitz R, Yoo HM, Liu X, Huang DW, Webster D, Young RM, Nakagawa M, Ceribelli M, Wright GW, Yang Y, Zhao H, Yu X, Xu W, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza L, Staudt LM. Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma. Cancer Cell. 2016 Apr 11; 29(4):494-507.

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Mak P, Li J, Samanta S, Mercurio AM. ER? regulation of NF-kB activation in prostate cancer is mediated by HIF-1. Oncotarget. 2015 Nov 24; 6(37):40247-54.

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Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M. NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 11 09; 28(5):582-598.

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Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nu?ez G, Dubyak G, Hu Y, Li X. IKKa negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30; 5:4977.

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