TOR Serine-Threonine Kinases

"TOR Serine-Threonine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.

Descriptor ID	D058570
MeSH Number(s)	D08.811.913.696.620.682.700.931 D12.776.476.925
Concept/Terms	TOR Serine-Threonine Kinases TOR Serine-Threonine Kinases Kinases, TOR Serine-Threonine Serine-Threonine Kinases, TOR TOR Serine Threonine Kinases Target of Rapamycin Proteins Rapamycin Proteins Target mTOR Serine-Threonine Kinases Kinases, mTOR Serine-Threonine Serine-Threonine Kinases, mTOR mTOR Serine Threonine Kinases Mechanistic Target of Rapamycin Protein FK506 Binding Protein 12-Rapamycin Associated Protein 1 FK506 Binding Protein 12 Rapamycin Associated Protein 1 TOR Kinases FKBP12-Rapamycin Associated Protein Associated Protein, FKBP12-Rapamycin FKBP12 Rapamycin Associated Protein Protein, FKBP12-Rapamycin Associated FKBP12-Rapamycin Complex-Associated Protein Complex-Associated Protein, FKBP12-Rapamycin FKBP12 Rapamycin Complex Associated Protein Protein, FKBP12-Rapamycin Complex-Associated RAFT-1 Protein Protein, RAFT-1 RAFT 1 Protein Rapamycin Target Protein Protein, Rapamycin Target Target Protein, Rapamycin mTOR Protein Protein, mTOR

Below are MeSH descriptors whose meaning is more general than "TOR Serine-Threonine Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
TOR Serine-Threonine Kinases [D12.776.476.925]

Below are MeSH descriptors whose meaning is related to "TOR Serine-Threonine Kinases".

Below are MeSH descriptors whose meaning is more specific than "TOR Serine-Threonine Kinases".

TOR Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
Mechanistic Target of Rapamycin Complex 2

publications

Timeline | Most Recent

This graph shows the total number of publications written about "TOR Serine-Threonine Kinases" by people in this website by year, and whether "TOR Serine-Threonine Kinases" was a major or minor topic of these publications.

Bar chart showing 96 publications over 20 distinct years, with a maximum of 10 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2004	0	2	2
2005	0	2	2
2006	0	2	2
2007	0	2	2
2008	0	8	8
2009	0	6	6
2010	1	7	8
2011	3	7	10
2012	2	3	5
2013	3	6	9
2014	4	2	6
2015	5	2	7
2016	4	3	7
2017	2	2	4
2018	0	4	4
2019	0	2	2
2020	0	2	2
2021	3	1	4
2022	1	4	5

Below are the most recent publications written about "TOR Serine-Threonine Kinases" by people in Profiles.

Luciano AK, Korobkina ED, Lyons SP, Haley JA, Fluharty SM, Jung SM, Kettenbach AN, Guertin DA. Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1. J Biol Chem. 2022 10; 298(10):102379.

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Cotton JL, Dang K, Hu L, Sun Y, Singh A, Rajurkar MS, Li Q, Wu X, Mao J. PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis. Cell Rep. 2022 07 19; 40(3):111125.

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Varco-Merth BD, Brantley W, Marenco A, Duell DD, Fachko DN, Richardson B, Busman-Sahay K, Shao D, Flores W, Engelman K, Fukazawa Y, Wong SW, Skalsky RL, Smedley J, Axthelm MK, Lifson JD, Estes JD, Edlefsen PT, Picker LJ, Cameron CM, Henrich TJ, Okoye AA. Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy. J Clin Invest. 2022 05 16; 132(10).

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Rushton MD, Saunderson EA, Patani H, Green MR, Ficz G. An shRNA kinase screen identifies regulators of UHRF1 stability and activity in mouse embryonic stem cells. Epigenetics. 2022 12; 17(12):1590-1607.

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Doxsey DD, Veinotte K, Shen K. A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of S. cerevisiae. Small GTPases. 2022 01; 13(1):327-334.

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Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleiner?schkamp F, Oh J, Godefroid N, Eltan M, G?ran T, Burtey S, Parotte MC, K?nig J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altm?ller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF. mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy. J Am Soc Nephrol. 2021 11; 32(11):2885-2899.

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Marchetti A, Rosellini M, Mollica V, Rizzo A, Tassinari E, Nuvola G, Cimadamore A, Santoni M, Fiorentino M, Montironi R, Massari F. The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What's the Story Morning Glory? Int J Mol Sci. 2021 Jun 09; 22(12).

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Muglia Amancio A, Mittereder L, Carletti A, Tosh KW, Green D, Antonelli LR, Gazzinelli RT, Sher A, Jankovic D. IFNs Reset the Differential Capacity of Human Monocyte Subsets to Produce IL-12 in Response to Microbial Stimulation. J Immunol. 2021 04 01; 206(7):1642-1652.

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Keane L, Antignano I, Riechers SP, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J, Graelmann F, McCormick PN, Esser J, Tejera D, Nagano A, Wang J, Chelala C, Biederbick Y, Halle A, Salomoni P, Heneka MT, Capasso M. mTOR-dependent translation amplifies microglia priming in aging mice. J Clin Invest. 2021 01 04; 131(1).

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Takahashi N, Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP, Brugge JS. 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. Mol Cell. 2020 12 03; 80(5):828-844.e6.

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