Interleukin-1 Receptor-Associated Kinases

"Interleukin-1 Receptor-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.

Descriptor ID	D053592
MeSH Number(s)	D08.811.913.696.620.682.700.526 D12.644.360.370 D12.776.476.384
Concept/Terms	Interleukin-1 Receptor-Associated Kinases Interleukin-1 Receptor-Associated Kinases Interleukin 1 Receptor Associated Kinases Kinases, Interleukin-1 Receptor-Associated Receptor-Associated Kinases, Interleukin-1 IRAK Kinases Kinases, IRAK IL-1 Receptor-Associated Kinase IL 1 Receptor Associated Kinase Kinase, IL-1 Receptor-Associated Receptor-Associated Kinase, IL-1 Interleukin-1 Receptor-Associated Kinase Interleukin 1 Receptor Associated Kinase Kinase, Interleukin-1 Receptor-Associated Receptor-Associated Kinase, Interleukin-1 Interleukin-1 Receptor-Associated Kinase 4 Interleukin-1 Receptor-Associated Kinase 4 Interleukin 1 Receptor Associated Kinase 4 IRAK-4 Kinase IRAK 4 Kinase Kinase, IRAK-4 Interleukin-1 Receptor-Associated Kinase 3 Interleukin-1 Receptor-Associated Kinase 3 Interleukin 1 Receptor Associated Kinase 3 IRAK-3 Kinase IRAK 3 Kinase Kinase, IRAK-3 Interleukin-1 Receptor-Associated Kinase 1 Interleukin-1 Receptor-Associated Kinase 1 Interleukin 1 Receptor Associated Kinase 1 IRAK-1 Kinase IRAK 1 Kinase Kinase, IRAK-1 Interleukin-1 Receptor-Associated Kinase 2 Interleukin-1 Receptor-Associated Kinase 2 Interleukin 1 Receptor Associated Kinase 2 IRAK-2 Kinase IRAK 2 Kinase Kinase, IRAK-2

Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Interleukin-1 Receptor-Associated Kinases [D12.644.360.370]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Interleukin-1 Receptor-Associated Kinases [D12.776.476.384]

Below are MeSH descriptors whose meaning is related to "Interleukin-1 Receptor-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-1 Receptor-Associated Kinases" by people in this website by year, and whether "Interleukin-1 Receptor-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 16 publications over 13 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2005	0	1	1
2006	0	1	1
2008	0	2	2
2009	2	1	3
2011	1	0	1
2012	1	0	1
2013	1	0	1
2016	0	1	1
2017	0	1	1
2018	1	0	1
2022	1	0	1
2023	0	1	1

Below are the most recent publications written about "Interleukin-1 Receptor-Associated Kinases" by people in Profiles.

Pereira M, Gazzinelli RT. Regulation of innate immune signaling by IRAK proteins. Front Immunol. 2023; 14:1133354.

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Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 08 16; 40(7):111225.

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De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. J Biol Chem. 2018 09 28; 293(39):15195-15207.

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Kalantari P, Harandi OF, Agarwal S, Rus F, Kurt-Jones EA, Fitzgerald KA, Caffrey DR, Golenbock DT. miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN). J Biol Chem. 2017 04 07; 292(14):5634-5644.

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Sun J, Li N, Oh KS, Dutta B, Vayttaden SJ, Lin B, Ebert TS, De Nardo D, Davis J, Bagirzadeh R, Lounsbury NW, Pasare C, Latz E, Hornung V, Fraser ID. Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use. Sci Signal. 2016 Jan 05; 9(409):ra3.

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Fernandes-Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald KA, Alnemri ES. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol. 2013 Oct 15; 191(8):3995-9.

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B?la SR, Dutra MS, Mui E, Montpetit A, Oliveira FS, Oliveira SC, Arantes RM, Antonelli LR, McLeod R, Gazzinelli RT. Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii. Infect Immun. 2012 Dec; 80(12):4298-308.

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Kim TW, Febbraio M, Robinet P, Dugar B, Greene D, Cerny A, Latz E, Gilmour R, Staschke K, Chisolm G, Fox PL, DiCorleto PE, Smith JD, Li X. The critical role of IL-1 receptor-associated kinase 4-mediated NF-?B activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis. J Immunol. 2011 Mar 01; 186(5):2871-80.

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Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM. Oncogenically active MYD88 mutations in human lymphoma. Nature. 2011 Feb 03; 470(7332):115-9.

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Errante PR, Prando C, Bustamante J, Arag?o Filho WC, Pereira PV, Rehder J, Casanova JL, Newburger P, Condino Neto A. Comment on "Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency". J Immunol. 2009 Sep 15; 183(6):3559.

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