Interleukin-1 Receptor-Associated Kinases

"Interleukin-1 Receptor-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.

Descriptor ID	D053592
MeSH Number(s)	D08.811.913.696.620.682.700.526 D12.644.360.370 D12.776.476.384
Concept/Terms	Interleukin-1 Receptor-Associated Kinases Interleukin-1 Receptor-Associated Kinases Interleukin 1 Receptor Associated Kinases Kinases, Interleukin-1 Receptor-Associated Receptor-Associated Kinases, Interleukin-1 IRAK Kinases Kinases, IRAK IL-1 Receptor-Associated Kinase IL 1 Receptor Associated Kinase Kinase, IL-1 Receptor-Associated Receptor-Associated Kinase, IL-1 Interleukin-1 Receptor-Associated Kinase Interleukin 1 Receptor Associated Kinase Kinase, Interleukin-1 Receptor-Associated Receptor-Associated Kinase, Interleukin-1 Interleukin-1 Receptor-Associated Kinase 4 Interleukin-1 Receptor-Associated Kinase 4 Interleukin 1 Receptor Associated Kinase 4 IRAK-4 Kinase IRAK 4 Kinase Kinase, IRAK-4 Interleukin-1 Receptor-Associated Kinase 3 Interleukin-1 Receptor-Associated Kinase 3 Interleukin 1 Receptor Associated Kinase 3 IRAK-3 Kinase IRAK 3 Kinase Kinase, IRAK-3 Interleukin-1 Receptor-Associated Kinase 1 Interleukin-1 Receptor-Associated Kinase 1 Interleukin 1 Receptor Associated Kinase 1 IRAK-1 Kinase IRAK 1 Kinase Kinase, IRAK-1 Interleukin-1 Receptor-Associated Kinase 2 Interleukin-1 Receptor-Associated Kinase 2 Interleukin 1 Receptor Associated Kinase 2 IRAK-2 Kinase IRAK 2 Kinase Kinase, IRAK-2

Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Interleukin-1 Receptor-Associated Kinases [D12.644.360.370]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Interleukin-1 Receptor-Associated Kinases [D12.776.476.384]

Below are MeSH descriptors whose meaning is related to "Interleukin-1 Receptor-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-1 Receptor-Associated Kinases" by people in this website by year, and whether "Interleukin-1 Receptor-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 20 publications over 16 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	1	1
2005	0	1	1
2006	0	1	1
2008	0	2	2
2009	2	1	3
2011	1	0	1
2012	1	0	1
2013	1	0	1
2016	0	1	1
2017	0	1	1
2018	1	0	1
2020	2	0	2
2022	1	0	1
2023	0	1	1
2024	1	0	1

Below are the most recent publications written about "Interleukin-1 Receptor-Associated Kinases" by people in Profiles.

Pereira M, Ramalho T, Andrade WA, Durso DF, Souza MC, Fitzgerald KA, Golenbock DT, Silverman N, Gazzinelli RT. The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024 Feb 27; 43(2):113795.

View in: PubMed
Pereira M, Gazzinelli RT. Regulation of innate immune signaling by IRAK proteins. Front Immunol. 2023; 14:1133354.

View in: PubMed
Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 08 16; 40(7):111225.

View in: PubMed
Qin Y, Pe?a G, Morcillo P, Singh S, Mosenthal AC, Livingston DH, Spolarics Z. X-Linked IRAK1 Polymorphism is Associated with Sex-Related Differences in Polymorphonuclear Granulocyte and Monocyte Activation and Response Variabilities. Shock. 2020 04; 53(4):434-441.

View in: PubMed
Morcillo P, Qin Y, Pe?a G, Mosenthal AC, Livingston DH, Spolarics Z. Directional X Chromosome Skewing of White Blood Cells from Subjects with Heterozygous Mosaicism for the Variant IRAK1 Haplotype. Inflammation. 2020 Feb; 43(1):370-381.

View in: PubMed
De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. J Biol Chem. 2018 09 28; 293(39):15195-15207.

View in: PubMed
Kalantari P, Harandi OF, Agarwal S, Rus F, Kurt-Jones EA, Fitzgerald KA, Caffrey DR, Golenbock DT. miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN). J Biol Chem. 2017 04 07; 292(14):5634-5644.

View in: PubMed
Sun J, Li N, Oh KS, Dutta B, Vayttaden SJ, Lin B, Ebert TS, De Nardo D, Davis J, Bagirzadeh R, Lounsbury NW, Pasare C, Latz E, Hornung V, Fraser ID. Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use. Sci Signal. 2016 Jan 05; 9(409):ra3.

View in: PubMed
Fernandes-Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald KA, Alnemri ES. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol. 2013 Oct 15; 191(8):3995-9.

View in: PubMed
B?la SR, Dutra MS, Mui E, Montpetit A, Oliveira FS, Oliveira SC, Arantes RM, Antonelli LR, McLeod R, Gazzinelli RT. Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii. Infect Immun. 2012 Dec; 80(12):4298-308.

View in: PubMed

People

Explore

Similar Concepts

Top Journals