 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 2 | 0 | 2 | | 1990 | 1 | 1 | 2 | | 1991 | 2 | 3 | 5 | | 1992 | 1 | 1 | 2 | | 1993 | 4 | 8 | 12 | | 1994 | 5 | 9 | 14 | | 1995 | 7 | 11 | 18 | | 1996 | 7 | 12 | 19 | | 1997 | 13 | 11 | 24 | | 1998 | 13 | 20 | 33 | | 1999 | 16 | 29 | 45 | | 2000 | 12 | 26 | 38 | | 2001 | 13 | 26 | 39 | | 2002 | 34 | 62 | 96 | | 2003 | 36 | 45 | 81 | | 2004 | 28 | 68 | 96 | | 2005 | 28 | 62 | 90 | | 2006 | 41 | 51 | 92 | | 2007 | 38 | 68 | 106 | | 2008 | 37 | 60 | 97 | | 2009 | 44 | 67 | 111 | | 2010 | 38 | 89 | 127 | | 2011 | 32 | 75 | 107 | | 2012 | 35 | 81 | 116 | | 2013 | 35 | 88 | 123 | | 2014 | 47 | 87 | 134 | | 2015 | 23 | 86 | 109 | | 2016 | 8 | 29 | 37 | | 2017 | 13 | 27 | 40 | | 2018 | 7 | 4 | 11 | | 2019 | 1 | 5 | 6 | | 2020 | 1 | 4 | 5 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Cao Y, Wang L, Lin LT, Wang XR, Ma SM, Yang NN, Fan H, Fisher M, Yang JW. Acupuncture attenuates cognitive deficits through a7nAChR mediated anti-inflammatory pathway in chronic cerebral hypoperfusion rats. Life Sci. 2021 Feb 01; 266:118732.
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Yao H, Sun L, Li J, Zhou X, Li R, Shao R, Zhang Y, Li L. A Novel Therapeutic siRNA Nanoparticle Designed for Dual-Targeting CD44 and Gli1 of Gastric Cancer Stem Cells. Int J Nanomedicine. 2020; 15:7013-7034.
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Yang T, Zang S, Wang Y, Zhu Y, Jiang L, Chen X, Zhang X, Cheng J, Gao R, Xiao H, Wang J. Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis. Toxicol Lett. 2020 Oct 15; 333:150-158.
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Bansal R, Mandrekar P, Mohanty SK, Weiskirchen R. Editorial: Macrophages in Liver Disease. Front Immunol. 2020; 11:1754.
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Saenz DT, Fiskus W, Mill CP, Perera D, Manshouri T, Lara BH, Karkhanis V, Sharma S, Horrigan SK, Bose P, Kadia TM, Masarova L, DiNardo CD, Borthakur G, Khoury JD, Takahashi K, Bhaskara S, Lin CY, Green MR, Coarfa C, Crews CM, Verstovsek S, Bhalla KN. Mechanistic basis and efficacy of targeting the ß-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors. Blood. 2020 04 09; 135(15):1255-1269.
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Gross-Vered M, Shmuel-Galia L, Zarmi B, Humphries F, Thaiss C, Salame TM, David E, Chappell-Maor L, Fitzgerald KA, Shai Y, Jung S. TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge. J Immunol. 2020 02 01; 204(3):707-717.
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Park CS, Lewis AH, Chen TJ, Bridges CS, Shen Y, Suppipat K, Puppi M, Tomolonis JA, Pang PD, Mistretta TA, Ma L, Green MR, Rau R, Lacorazza HD. A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Blood. 2019 11 28; 134(22):1960-1972.
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Qureshi W, Santaren ID, Hanley AJ, Watkins SM, Lorenzo C, Wagenknecht LE. Risk of diabetes associated with fatty acids in the de novo lipogenesis pathway is independent of insulin sensitivity and response: the Insulin Resistance Atherosclerosis Study (IRAS). BMJ Open Diabetes Res Care. 2019; 7(1):e000691.
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Sokolova M, Sjaastad I, Louwe MC, Alfsnes K, Aronsen JM, Zhang L, Haugstad SB, Bendiksen BA, Øgaard J, Bliksøen M, Lien E, Berge RK, Aukrust P, Ranheim T, Yndestad A. NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity. Front Immunol. 2019; 10:1621.
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D'Ambrosio EA, Drake WR, Mashayekh S, Ukaegbu OI, Brown AR, Grimes CL. Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective. Bioorg Med Chem Lett. 2019 05 15; 29(10):1153-1161.
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