Signal Transduction

"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.

Bar chart showing 2473 publications over 31 distinct years, with a maximum of 147 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	8	11	19
1997	14	9	23
1998	14	20	34
1999	15	27	42
2000	13	24	37
2001	16	26	42
2002	32	56	88
2003	35	40	75
2004	31	62	93
2005	27	60	87
2006	38	50	88
2007	35	72	107
2008	39	61	100
2009	42	68	110
2010	38	91	129
2011	42	81	123
2012	34	91	125
2013	41	99	140
2014	44	103	147
2015	31	98	129
2016	29	86	115
2017	32	75	107
2018	33	62	95
2019	25	73	98
2020	15	55	70
2021	18	50	68
2022	3	24	27
2023	7	23	30
2024	19	24	43
2025	10	45	55
2026	2	25	27

Below are the most recent publications written about "Signal Transduction" by people in Profiles.

Matteucci KC, Leite NPS, Assis PA, Hirako IC, Pioto F, Ojelabi O, Toller-Kawahisa JE, Vaz LG, Costa DL, da Silva JS, Alves-Filho JC, Gazzinelli RT. Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1a axis plays a key role in host resistance to Plasmodium infection. Elife. 2026 Jul 27; 13.

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Trostle AJ, Cherubino MA, Sokolowskei D, Sammarco MC, McCusker CD, Tower RJ. Conserved anterior/posterior tissue asymmetry encodes proximal/distal positional information during axolotl limb regeneration. Cell Rep. 2026 Jul 28; 45(7):117669.

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Ferreira V, Folgueira C, Hitos AB, Montes San-Lorenzo ?, Est?vez-Salguero ?, Porteiro B, Davis RJ, L?pez M, Sabio G, Rada P, Valverde ?M. A hypothalamus-liver-skeletal muscle axis controlled by JNK1 and FGF21 mediates olanzapine-induced insulin resistance in an intraperitoneal treatment in male mice. Redox Biol. 2026 Sep; 95:104286.

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Velentzas PD, Chai F, Baehrecke EH. The pyruvate transporter hermes regulates autophagy and health by modulating ROS production. Cell Rep. 2026 Jul 28; 45(7):117574.

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Biswas K, Moore C, Rogers H, Wani KA, Mushtaq A, Pukkila-Worley R, Higgins DP, Walker AK, Mullen GP, Rand JB, Francis MM. Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling. Elife. 2026 Jun 08; 14.

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Lentini G, Coppolino F, Fam? A, De Gaetano GV, Grasso F, Fiore L, Berbiglia A, Carnevale S, Venza I, Lien E, Venza M, Jaillon S, Teti G, Beninati C. Caspase-8 silences cell death-independent constitutive immune activation driven by tonic TNF-a. EMBO Rep. 2026 Jul; 27(14):4054-4078.

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Dhillon BK, Blimkie TM, Idoko OT, Ford R, Angelidou A, Ben-Othman R, Montante S, Amenyogbe N, Dibassey T, Diray-Arce J, Falsafi R, Imam A, McEnaney K, Odumade OA, Ozonoff A, Pomat WS, Richmond PC, Smolen KK, Wariri O, Levy O, van den Biggelaar AHJ, Kampmann B, Kollmann TR, Lee AHY, Hancock REW. Population-specific heterogeneity in ontogeny of the broadly-conserved blood transcriptional program during the first week of life. Nat Commun. 2026 06 01; 17(1).

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Kim JM, Yang YS, Xie J, Kang CM, Cho YC, Park KH, Gong F, Sato T, Kim BJ, Gao G, Shim JH. USP24-dependent STAT2 stabilization mediates physiologic and pathologic bone formation. Cell Death Dis. 2026 May 30; 17(1).

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Collado-Sole A, Borjini N, Zhai J, Ruiz-Pino F, Soria-Alcaide G, Folgueira C, Garc?a-Vilela C, Romero-de la Rosa B, Lopez V, Zouaghi Y, Jacobs A, Mora-Romero B, Barranco A, Yoldi G, Rizzoti K, Sabio G, Perez-Chacon G, Santamaria PG, Esteban JA, Journiac N, Prevot V, Pascual A, Fern?ndez-Chac?n R, Tena-Sempere M, Pitteloud N, Gonzalez-Suarez E. Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis. Science. 2026 May 21; 392(6800):eaeb6999.

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Lee Y, Ouyang Q, Ma L, Fleishman M, Riaz HA, Schmidt M, Dupree JL, Mondal A, Mohanty P, Mittal J, Beckstein O, Lambright DG, Morrow EM. Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling. Nat Commun. 2026 May 08; 17(1).

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