Disks Large Homolog 4 Protein

"Disks Large Homolog 4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.

Descriptor ID	D000076122
MeSH Number(s)	D08.811.913.696.650.450.750 D12.644.360.265 D12.776.476.265 D12.776.543.219 D12.776.631.224
Concept/Terms	Disks Large Homolog 4 Protein Disks Large Homolog 4 Protein Postsynaptic Density Protein 95 Discs Large Homolog 4 Protein SAP-90 Protein SAP 90 Protein PSD95 Protein PSD-95 Protein PSD 95 Protein Synapse-Associated Protein 90 Synapse Associated Protein 90 SAP90 Protein

Below are MeSH descriptors whose meaning is more general than "Disks Large Homolog 4 Protein".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Phosphate Group Acceptor) [D08.811.913.696.650]
Guanylate Kinases [D08.811.913.696.650.450]
Disks Large Homolog 4 Protein [D08.811.913.696.650.450.750]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Disks Large Homolog 4 Protein [D12.644.360.265]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Disks Large Homolog 4 Protein [D12.776.476.265]
Membrane Proteins [D12.776.543]
Disks Large Homolog 4 Protein [D12.776.543.219]
Nerve Tissue Proteins [D12.776.631]
Disks Large Homolog 4 Protein [D12.776.631.224]

Below are MeSH descriptors whose meaning is related to "Disks Large Homolog 4 Protein".

Below are MeSH descriptors whose meaning is more specific than "Disks Large Homolog 4 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Disks Large Homolog 4 Protein" by people in this website by year, and whether "Disks Large Homolog 4 Protein" was a major or minor topic of these publications.

Bar chart showing 17 publications over 14 distinct years, with a maximum of 2 publications in 2007 and 2013 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	1	1
1997	0	1	1
2003	0	1	1
2004	0	1	1
2007	0	2	2
2010	0	1	1
2011	0	1	1
2013	0	2	2
2014	0	1	1
2016	0	1	1
2017	1	0	1
2019	2	0	2
2020	0	1	1

Below are the most recent publications written about "Disks Large Homolog 4 Protein" by people in Profiles.

Hill MD, Goyal M, Menon BK, Nogueira RG, McTaggart RA, Demchuk AM, Poppe AY, Buck BH, Field TS, Dowlatshahi D, van Adel BA, Swartz RH, Shah RA, Sauvageau E, Zerna C, Ospel JM, Joshi M, Almekhlafi MA, Ryckborst KJ, Lowerison MW, Heard K, Garman D, Haussen D, Cutting SM, Coutts SB, Roy D, Rempel JL, Rohr AC, Iancu D, Sahlas DJ, Yu AYX, Devlin TG, Hanel RA, Puetz V, Silver FL, Campbell BCV, Chapot R, Teitelbaum J, Mandzia JL, Kleinig TJ, Turkel-Parrella D, Heck D, Kelly ME, Bharatha A, Bang OY, Jadhav A, Gupta R, Frei DF, Tarpley JW, McDougall CG, Holmin S, Rha JH, Puri AS, Camden MC, Thomalla G, Choe H, Phillips SJ, Schindler JL, Thornton J, Nagel S, Heo JH, Sohn SI, Psychogios MN, Budzik RF, Starkman S, Martin CO, Burns PA, Murphy S, Lopez GA, English J, Tymianski M. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial. Lancet. 2020 03 14; 395(10227):878-887.

View in: PubMed
Laursen L, Karlsson E, Gianni S, Jemth P. Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95. J Biol Chem. 2020 02 14; 295(7):1992-2000.

View in: PubMed
Mardones MD, Jorquera PV, Herrera-Soto A, Ampuero E, Bustos FJ, van Zundert B, Varela-Nallar L. PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus. J Chem Neuroanat. 2019 07; 98:117-123.

View in: PubMed
Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henr?quez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, H?rtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice. Brain. 2017 Dec 01; 140(12):3252-3268.

View in: PubMed
Ampuero E, Jury N, H?rtel S, Marzolo MP, van Zundert B. Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons. J Cell Physiol. 2017 05; 232(5):1187-1199.

View in: PubMed
Bustos FJ, Varela-Nallar L, Campos M, Henriquez B, Phillips M, Opazo C, Aguayo LG, Montecino M, Constantine-Paton M, Inestrosa NC, van Zundert B. PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors. PLoS One. 2014; 9(4):e94037.

View in: PubMed
Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M, van Zundert B. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Mol Cell Neurosci. 2013 Nov; 57:130-43.

View in: PubMed
Yoshii A, Zhao JP, Pandian S, van Zundert B, Constantine-Paton M. A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. J Neurosci. 2013 May 08; 33(19):8472-82.

View in: PubMed
Sim S, Antolin S, Lin CW, Lin Y, Lin YX, Lois C. Increased cell-intrinsic excitability induces synaptic changes in new neurons in the adult dentate gyrus that require Npas4. J Neurosci. 2013 May 01; 33(18):7928-40.

View in: PubMed
Br?tane BT, Cui H, Cook DJ, Bouley J, Tymianski M, Fisher M. Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor. Stroke. 2011 Nov; 42(11):3265-70.

View in: PubMed

People

Explore

Similar Concepts

Top Journals