 I-kappa B Proteins
"I-kappa B Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.
| Descriptor ID |
D020672
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| MeSH Number(s) |
D12.644.360.378 D12.776.260.420 D12.776.476.381 D12.776.930.326
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| Concept/Terms |
I-kappa B Proteins- I-kappa B Proteins
- I kappa B Proteins
- IkB DNA-Binding Proteins
- IkB DNA Binding Proteins
- I kappa B
- I-kappa B
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Below are MeSH descriptors whose meaning is more general than "I-kappa B Proteins".
Below are MeSH descriptors whose meaning is more specific than "I-kappa B Proteins".
This graph shows the total number of publications written about "I-kappa B Proteins" by people in this website by year, and whether "I-kappa B Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 0 | 2 | | 1994 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1998 | 2 | 0 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 4 | 2 | 6 | | 2003 | 1 | 1 | 2 | | 2004 | 1 | 1 | 2 | | 2005 | 1 | 2 | 3 | | 2007 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2015 | 0 | 2 | 2 |
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Below are the most recent publications written about "I-kappa B Proteins" by people in Profiles.
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Mak P, Li J, Samanta S, Mercurio AM. ERß regulation of NF-kB activation in prostate cancer is mediated by HIF-1. Oncotarget. 2015 Nov 24; 6(37):40247-54.
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Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts. J Exp Med. 2015 Jul 27; 212(8):1283-301.
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Rajurkar M, De Jesus-Monge WE, Driscoll DR, Appleman VA, Huang H, Cotton JL, Klimstra DS, Zhu LJ, Simin K, Xu L, McMahon AP, Lewis BC, Mao J. The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1038-47.
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Kim JK. Endothelial nuclear factor ?B in obesity and aging: is endothelial nuclear factor ?B a master regulator of inflammation and insulin resistance? Circulation. 2012 Mar 6; 125(9):1081-3.
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Balasubramanian S, Fan M, Messmer-Blust AF, Yang CH, Trendel JA, Jeyaratnam JA, Pfeffer LM, Vestal DJ. The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein. J Biol Chem. 2011 Jun 03; 286(22):20054-64.
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Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O'Keefe RJ. Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C310-20.
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Ravi D, Muniyappa H, Das KC. Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. Mol Cell Biochem. 2008 Jan; 308(1-2):193-200.
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Chakrabarti S, Blair P, Wu C, Freedman JE. Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects. J Cardiovasc Pharmacol. 2007 Oct; 50(4):449-57.
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Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. J Cell Biochem. 2005 Dec 15; 96(6):1262-73.
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Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J. 2006 Jan 11; 25(1):129-38.
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